3-{4-[(6-{[2-hydroxy-2-(5-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}hexyl)oxy]butyl}benzenesulfonamide | 662111-27-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 3-{4-[(6-{[2-hydroxy-2-(5-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}hexyl)oxy]butyl}benzenesulfonamide
• 英文别名: 3-[4-[6-[[2-hydroxy-2-(5-hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl)ethyl]amino]hexoxy]butyl]benzenesulfonamide
• CAS: 662111-27-5
• 化学式: C₂₆H₃₇N₃O₇S
• 分子量: 535.662
• InChiKey: LZYVMHWVSJNVDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  37
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  169
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• Arylethanolamine beta2-adrenoreceptor agonist compounds
  申请人：Biggadike Keith

  公开号：US20060111344A1

  公开（公告）日：2006-05-25

  The present invention relates to compounds of formula (I) as defined herein and salts or solvates thereof. Processes for preparing these compounds and pharmaceutical formulations containing them are also disclosed, as well as methods for the prophylaxis of treatment of a clinical condition using such compounds.

  本发明涉及以下式(I)的化合物及其盐或溶剂合物。本发明还揭示了制备这些化合物和含有它们的制药配方，以及使用这些化合物预防或治疗临床病症的方法。
• ARYLETHANOLAMINE BETA2-ADRENORECEPTOR AGONIST COMPOUNDS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1525180A2

  公开（公告）日：2005-04-27
• US7402598B2
  申请人：——

  公开号：US7402598B2

  公开（公告）日：2008-07-22
• [EN] MEDICINAL COMPOUNDS<br/>[FR] COMPOSES MEDICAMENTEUX
  申请人：GLAXO GROUP LTD

  公开号：WO2004016578A2

  公开（公告）日：2004-02-26

  The present invention concerns compounds of formula (I) and salts, solvates, and physiologically functional derivatives thereof, wherein: R1 is hydrogen or -XSO2NR6R7; R2 and R3 are independently selected from hydrogen, C1-6 alkyl, C1-6 alkoxy, halo, phenyl and C1-6 haloalkyl and Ar is a group selected from and. Processes for preparing said compounds and pharmaceutical formulations containing them are also described. Compounds of formula (I) are useful in the treatment of respiratory diseases