1,1-二苯基-2-(4-甲氧基苯基)乙醇 | 19838-89-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 1,1-二苯基-2-(4-甲氧基苯基)乙醇
• 英文名称: 2-(4-methoxyphenyl)-1,1-diphenylethanol
• 英文别名: 2-(4-methoxyphenyl)-1,1-diphenylethan-1-ol；1,1-diphenyl-2-(4-methoxyphenyl)ethanol；2-(4-Methoxy-phenyl)-1,1-diphenyl-aethanol；2-Hydroxy-2.2-diphenyl-1-(4-methoxy-phenyl)-aethan；Diphenylanisylcarbinol
• CAS: 19838-89-2
• 化学式: C₂₁H₂₀O₂
• 分子量: 304.389
• InChiKey: COGJLXLEBRRRBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,1-二苯基-2-(4-甲氧基苯基)乙醇 在 bis-triphenylphosphine-palladium(II) chloride 、 甲酸 、 potassium phenolate 、 溴 、 甲基三辛基氯化铵 、 potassium carbonate 、 三苯基膦 作用下， 以 氯仿 、 水 、 甲苯 为溶剂， 反应 28.08h， 生成 2,6-Bis[4-[1-(4-methoxyphenyl)-2,2-diphenylethenyl]phenyl]pyridine
  参考文献：
  名称：

  Pyridine-cored V-shaped π-conjugated oligomers: synthesis and optical properties

  摘要：

  A new series of V-shaped pyridine-cored pi-conjugated oligomers are synthesized utilizing two-fold Heck/Suzuki coupling reactions. Optical properties of these compounds (lambda(max)=390-449 nm, phi(eta)=79-5%, in solutions) are discussed. They are shown to be thermally stable and soluble in common organic solvents. Stilbenoid oligomers exhibited much higher fluorescence quantum yields than tri- and tetra-phenylethylene substituted oligomers in solutions. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.06.096
• 作为产物：
  描述：

  对甲氧基苯乙酸 在 乙醚 、 硫酸 作用下， 生成 1,1-二苯基-2-(4-甲氧基苯基)乙醇
  参考文献：
  名称：

  36.氯对亚磺酸铵水溶液的作用

  摘要：

  DOI：

  10.1039/jr9480000147

文献信息

• A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow
  作者：Yiding Chen、Oliver May、David C. Blakemore、Steven V. Ley

  DOI：10.1021/acs.orglett.9b02307

  日期：2019.8.2

  Mild cross-coupling reaction between benzylboronic esters with carbonyl compounds and some imines was achieved under visible-light-induced iridium-catalyzed photoredox conditions. Functional group tolerance was demonstrated by 51 examples, including 13 heterocyclic compounds. Gram-scale reaction was realized through the use of computer-controlled continuous flow photoreactors.

  在可见光诱导的铱催化的光氧化还原条件下，苄基硼酸酯与羰基化合物和一些亚胺之间实现了温和的交叉偶联反应。通过51个实例（包括13个杂环化合物）证明了官能团的耐受性。革兰氏反应是通过使用计算机控制的连续流光反应器实现的。
• A Kinetic Evaluation of Carbon−Hydrogen, Carbon−Carbon, and Carbon−Silicon Bond Activation in Benzylic Radical Cations
  作者：Mauro Freccero、Albert Pratt、Angelo Albini、Conor Long

  DOI：10.1021/ja970940s

  日期：1998.1.1

  A detailed study of the competition between C−C, C−H, and C−Si bond fragmentation in a series of 4-methoxy-α-substituted toluene radical cations (1•+), involving both product studies and kinetic analysis, is presented. C−C bond fragmentation occurs with several radical cations in acetonitrile. The rate constants for such processes, determined by laser flash photolysis, varied from 2.8 × 104 (1c•+)

  对一系列 4-甲氧基-α-取代的甲苯自由基阳离子 (1•+) 中 C-C、C-H 和 C-Si 键断裂之间竞争的详细研究，包括产品研究和动力学分析，是呈现。乙腈中的几个自由基阳离子会发生 C-C 键断裂。此类过程的速率常数由激光闪光光解确定，从 2.8 × 104 (1c•+) 到 1.53 × 106 (1f•+) s-1 不等。C-C 键断裂的活化参数的特点是低活化焓约为 30 kJ mol-1，负活化熵在 -34 至 -55 J mol-1 K-1 范围内。自由基阳离子的去质子化始终是由亲核试剂 [硝酸铈 (IV) 硝酸铵 (CAN) 或硝酸根阴离子] 诱导的二级过程，二级速率常数从 7.7 × 107 (1h•+) 到 8。8 × 108 (1i•+) M-1 s-1 在纯乙腈中（CAN 辅助）和从 0.4 × 108 (1j•+) 到 7.1 × 108 (1i•+) M-1 s-1
• Palladium-catalysed direct synthesis of benzo[b]thiophenes from thioenols
  作者：Kiyofumi Inamoto、Yukari Arai、Kou Hiroya、Takayuki Doi

  DOI：10.1039/b811362a

  日期：——

  The one-pot conversion of thioenols into benzo[b]thiophenes was achieved by using a simple palladium catalyst such as PdCl(2) or PdCl(2)(cod).

  通过使用简单的钯催化剂（例如PdCl（2）或PdCl（2）（cod）），将单烯醇单锅转化为苯并[b]噻吩。
• Antihypercholesterolemic beta-lactones
  申请人：Merck & Co., Inc.

  公开号：EP0293132A1

  公开（公告）日：1988-11-30

  The compounds of the following general structural formula (I) are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase inhibitors and useful as antihyper­cholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyper­lipidemia and familial hypercholesterolemia.

  以下结构通式(I)的化合物 是 3-羟基-3-甲基戊二酰辅酶 A（HMG-CoA）合成酶抑制剂，可作为抗高胆固醇血症药物用于治疗对抑制胆固醇生物合成有用的疾病，如动脉硬化、高脂血症和家族性高胆固醇血症。
• Treatment of diabetic ketoacidosis
  申请人：MERCK & CO. INC.

  公开号：EP0349047A2

  公开（公告）日：1990-01-03

  There is disclosed the use of β-lactone alkylene carboxylic acids and derivatives thereof, which are known compounds, for the use of treating diabetic ketoacidosis. The compounds are administered orally or parenterally and compositions containing the β-lactone alkylene carboxylic acid compounds as the active ingredient are also disclosed.

  公开了β-内酯烯烃羧酸及其衍生物（已知化合物）用于治疗糖尿病酮症酸中毒的用途。这些化合物口服或肠外给药，还公开了含有β-内酯烯烃羧酸化合物作为活性成分的组合物。