6-hydroxy-1-(piperidin-4-yl)-1,4-dihydro-2H-3,1-benzoxazin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 6-hydroxy-1-(piperidin-4-yl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
• 英文别名: 6-hydroxy-1-piperidin-4-yl-4H-3,1-benzoxazin-2-one
• 化学式: C₁₃H₁₆N₂O₃
• 分子量: 248.282
• InChiKey: AOLYWIYUTFRDLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  61.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Benzoxazinone-derived compounds, their preparation and use as medicaments
  申请人：——

  公开号：US20040058920A1

  公开（公告）日：2004-03-25

  The present invention relates to Benzoxazinone-derived compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans or animals.

  本发明涉及一般式（I）的苯并噁唑酮衍生物，其制备方法，包含这些化合物的药物以及它们用于制备用于治疗人类或动物的药物的用途。
• [EN] BENZOXAZINONE-DERIVED COMPOUNDS, THEIR PREPARATION UND USE AS MEDICAMENTS<br/>[FR] COMPOSES DERIVES DE BENZOXAZINONE, LEUR PREPARATION ET UTILISATION COMME MEDICAMENTS
  申请人：ESTEVE LAB DR ESTEVE S A

  公开号：WO2003084952A1

  公开（公告）日：2003-10-16

  The present invention relates to Benzoxazinone-derived compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans or animals.

  本发明涉及一般公式（I）的苯并噁唑酮衍生物，其制备方法，包含这些化合物的药物以及它们用于制备用于治疗人类或动物的药物的用途。
• Benzoxazinone derivatives, their preparation and use as medicaments
  申请人：——

  公开号：US20040067941A1

  公开（公告）日：2004-04-08

  The present invention relates to new compounds of general formula (I), as well as to their physiologically acceptable salts, the procedures for their preparation, the intermediate compounds for obtaining them, the application of the compounds of general formula (I) as medicaments in the prevention and treatment of disorders of the Central nervous System and to the pharmaceutical compositions containing them. 1

  本发明涉及一般式（I）的新化合物，以及它们的生理可接受的盐，其制备方法，获得它们的中间化合物，将一般式（I）的化合物作为药物在预防和治疗中枢神经系统疾病方面的应用，以及包含它们的制药组合物。
• BENZOXAZINONE DERIVATIVES, THE PREPARATION AND USE THEREOF AS MEDICAMENTS
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1500654A1

  公开（公告）日：2005-01-26

  The present invention relates to new compounds of general formula (I), as well as to their physiologically acceptable salts, the procedures for their preparation, the intermediate compounds for obtaining them, the application of the compounds of general formula (I) as medicaments in the prevention and treatment of disorders of the Central nervous System and to the pharmaceutical compositions containing them.

  本发明涉及通式（I）的新化合物及其生理上可接受的盐、其制备程序、获得这些化合物的中间化合物、通式（I）化合物作为药物在预防和治疗中枢神经系统疾病中的应用以及含有这些化合物的药物组合物。
• BENZOXAZINONE-DERIVED COMPOUNDS, THEIR PREPARATION UND USE AS MEDICAMENTS
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1497285A1

  公开（公告）日：2005-01-19