N-(10-oxo-3,11,21-triazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,13,15,17,19-nonaen-12-yl)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(10-oxo-3,11,21-triazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,13,15,17,19-nonaen-12-yl)acetamide
• 化学式: C₂₀H₁₄N₄O₂
• 分子量: 342.357
• InChiKey: UXTGICMRNGSLRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  74.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙腈 、 色氨酸A 在 ammonium cerium(IV) nitrate 作用下， 反应 6.0h， 以25%的产率得到N-(10-oxo-3,11,21-triazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,13,15,17,19-nonaen-12-yl)acetamide
  参考文献：
  名称：

  Novel quinazoline–quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities

  摘要：

  Two new synthetic analogues of luotonins A and F, 7-acetylaminoluotonin A (6) and 3-[3H(quinazolino-4-one)]quinoline (7) were synthesized. The new analogues, along with four natural quinazoline-quinoline alkaloids, luotonins A (1), B (2), E (3), F (4) and a synthetic deoxoluotonin F (5), showed cytotoxic activity (IC50 1.8-40.0 mug/mL) and DNA topoisomerase II inhibition at a concentration of 25 muM. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.12.048

文献信息

• Novel quinazoline–quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities
  作者：Zhongze Ma、Yoshio Hano、Taro Nomura、Yingjie Chen

  DOI：10.1016/j.bmcl.2003.12.048

  日期：2004.3

  Two new synthetic analogues of luotonins A and F, 7-acetylaminoluotonin A (6) and 3-[3H(quinazolino-4-one)]quinoline (7) were synthesized. The new analogues, along with four natural quinazoline-quinoline alkaloids, luotonins A (1), B (2), E (3), F (4) and a synthetic deoxoluotonin F (5), showed cytotoxic activity (IC50 1.8-40.0 mug/mL) and DNA topoisomerase II inhibition at a concentration of 25 muM. (C) 2003 Elsevier Ltd. All rights reserved.