1,2,3,4-四氢甲氧基萘 | 71735-16-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 中文名称: 1,2,3,4-四氢甲氧基萘
• 中文别名: 1,2,3,4-四氢-1-甲氧基-萘
• 英文名称: 1-methoxy tetralin
• 英文别名: 1,2,3,4-tetrahydro-1-methoxy-naphthalene；1,2,3,4-tetrahydro-1-methoxynaphthalene；1-methoxy-1,2,3,4-tetrahydronaphthalene；1-methoxytetralin；methyl-(1,2,3,4-tetrahydro-[1]naphthyl)-ether；Methyl-(1,2,3,4-tetrahydro-[1]naphthyl)-aether
• CAS: 71735-16-5
• 化学式: C₁₁H₁₄O
• 分子量: 162.232
• InChiKey: IBRIMMDNSPFZMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,2,3,4-四氢甲氧基萘 在 cytochrome P₄₅₀ monooxygenase P_450RpMO 作用下， 生成 1,2,3,4-四氢-1-萘酚
  参考文献：
  名称：

  Rapid probing of the reactivity of P450 monooxygenases from the CYP116B subfamily using a substrate-based method

  摘要：

  设计了四种O-甲基化底物作为探针，用于检测IV型P450的指纹。

  DOI：

  10.1039/c6nj00809g
• 作为产物：
  描述：

  1,2,3,4-四氢-1-萘酚 在 甲醇 、 硫酸 作用下， 生成 1,2,3,4-四氢甲氧基萘
  参考文献：
  名称：

  Tschishewsskaja; Ideltschik, Zhurnal Obshchei Khimii, 1957, vol. 27, p. 83,86

  摘要：

  DOI：

文献信息

• [EN] SUBSTITUTED THIAZOLE COMPOUNDS<br/>[FR] COMPOSÉS THIAZOLES SUBSTITUÉS
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014086697A1

  公开（公告）日：2014-06-12

  The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are LMP7 inhibitors and may be useful in treating associated inflammatory diseases and disorders such as, for example, rheumatoid arthritis, lupus and irritable bowel disease.

  这项发明涉及式(I)的化合物及其药学上可接受的盐。此外，本发明涉及制造和使用式(I)的化合物的方法，以及含有这种化合物的药物组合物。式(I)的化合物是LMP7抑制剂，可能在治疗相关的炎症性疾病和紊乱方面有用，例如类风湿性关节炎、红斑狼疮和肠易激综合征。
• Indium(<scp>i</scp>)-catalyzed alkyl–allyl coupling between ethers and an allylborane
  作者：Hai Thanh Dao、Uwe Schneider、Shū Kobayashi

  DOI：10.1039/c0cc03673k

  日期：——

  An efficient method for alkyl–allyl cross-coupling between ethers and a 9-BBN-derived allylborane catalyzed by indium(I) triflate has been developed. The allylborane proved to be essential to obtain the desired products in high yields. The reaction displayed good substrate scope including high functional group tolerance.

  开发了一种高效的方法，用于通过三氟甲磺酸铟（I）催化的乙醚与9-BBN衍生烯丙基硼烷之间的烷基-烯丙基交联偶联反应。实验证明，烯丙基硼烷对于以高产率获得所需产物至关重要。该反应表现出良好的底物范围，包括对多种官能团的高容忍度。
• Iron-Catalyzed π-Activated C-O Ether Bond Cleavage with C-C and C-H Bond Formation
  作者：Xiaohui Fan、Xiao-Meng Cui、Yong-Hong Guan、Lin-An Fu、Hao Lv、Kun Guo、Hong-Bo Zhu

  DOI：10.1002/ejoc.201301372

  日期：2014.1

  A novel and efficient allylic alkylation reaction between π-activated ethers and allylsilane was realized under mild conditions through iron(III)-catalyzed C–O ether bond cleavage. The present protocol provides an attractive approach for the construction of sp3–sp3 C–C bonds and can be potentially applied for the selective reduction of benzyl and allyl ethers to their corresponding hydrocarbon compounds

  通过铁（III）催化的 C-O 醚键断裂，在温和条件下实现了 π 活化醚和烯丙基硅烷之间新型高效的烯丙基烷基化反应。本协议为构建 sp3-sp3 C-C 键提供了一种有吸引力的方法，并且可以通过使用三乙基硅烷作为氢化物转移试剂将苄基和烯丙基醚选择性还原为其相应的碳氢化合物。
• Iron-catalyzed N-alkylation using π-activated ethers as electrophiles
  作者：Xiaohui Fan、Lin-An Fu、Na Li、Hao Lv、Xiao-Meng Cui、Yuan Qi

  DOI：10.1039/c3ob27128e

  日期：——

  A new method for the synthesis of diverse N-alkylation compounds was developed via an iron-catalyzed etheric Csp3–O cleavage with the C–N bond formation in the reaction of π-activated ethers with various nitrogen-based nucleophiles. In addition, the mechanism of this reaction was investigated.

  通过铁催化的醚类Csp3–O键断裂并伴随C–N键形成反应，开发了一种合成多种N-烷基化化合物的新方法，即在π活性醚与各种含氮亲核试剂的反应中生成C–N键。此外，还研究了该反应的机理。
• Benzobicyclic carboxamide 5-HT3 antagonists
  申请人：Rorer Pharmaceutical Corp.

  公开号：US04920227A1

  公开（公告）日：1990-04-24

  Certain specific substituted benzobicyclic carboxamides and their valuable use as 5-HT3 antagonists having CNS and gastric prokenetic activity void of any significant D.sub.2 receptor binding activity are disclosed.

  某些特定的替代苯并环戊二酰胺及其作为5-HT3拮抗剂的宝贵用途被披露，具有中枢神经系统和胃动力活性，且不具有任何显著的D.sub.2受体结合活性。