1,2-环庚二胺,(1R,2S)-rel- | 251979-90-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1,2-环庚二胺,(1R,2S)-rel-
• 英文名称: cis-cycloheptane-1,2-diamine
• 英文别名: cis-1,2-diaminocycloheptane；cis-cycloheptane-1,2-diyldiamine；cis-Cycloheptan-1,2-diyldiamin；(1S,2R)-cycloheptane-1,2-diamine
• CAS: 251979-90-5
• 化学式: C₇H₁₆N₂
• 分子量: 128.217
• InChiKey: DBBUVLSRTWYISN-KNVOCYPGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2E)-2,3-二氰基-2-丁烯二酸 1,4-二乙基酯 、 1,2-环庚二胺,(1R,2S)-rel- 以 乙腈 为溶剂， 反应 1.0h， 以32%的产率得到cis-(Z)-3-(α-cyano-α-ethoxycarbonylmethylene)-1,3,4,4a,5,6,7,8,9,9a-decahydro-2H-cycloheptapyrazin-2-one
  参考文献：
  名称：

  A Convenient Synthesis of (Z)-3- (a-Cyano-a-alkoxycarbonylmethylene)-2-piperazinones and Their Derivatives

  摘要：

  (Z)-3-(alpha-Cyano-alpha-alkoxycarbonylmethylene)-2-piperazinone derivatives (3) and trans-(Z)-3-(alpha-cyano-alpha-alkoxycarbonylmethylene)-octahydro-2 (1H)-quinoxalinone derivatives (5) possessing various alkoxycarbonyl groups are prepared directly from the reaction of dialkyl (E)-2,3-dicyanobutenedioates (1) with ethylenediamine (2) and with trans-1,2-diaminocyclohexane (4), respectively. Furthermore, cis-1,2-diaminocycloheptane (6) and meso-2,3-diaminobutane (8) were reacted with the diethyl ester Ib to give cis-(Z)-3-(alpha-cyano-alpha-ethoxycarbonyl-methylene)decahydro-2H-cycloheptapyrazin-2-one (7) and cis-(Z)-3-(alpha-cyanoyano-alpha-ethoxycarbonylmethylene)-5,6-dimethyl-2-piperazinone (9), respectively. The structural studies of 3, 5, 7, and 9 were carried out by NMR experiments in some details.

  DOI：

  10.3987/com-99-8645
• 作为产物：
  描述：

  cis-octahydro-cyclohePtimidazol-2-one 在 硫酸 作用下， 生成 1,2-环庚二胺,(1R,2S)-rel-
  参考文献：
  名称：

  Process for the production of cycloaliphatic 1, 2-diamines

  摘要：

  公开号：

  US02850532A1

文献信息

• [EN] PYRAZOLOPYRIMIDINE INHIBITORS OF IRAK4 ACTIVITY<br/>[FR] INHIBITEURS DE L'ACTIVITÉ D'IRAK4 À BASE DE PYRAZOLOPYRIMIDINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2016144846A1

  公开（公告）日：2016-09-15

  The present invention relates to pyrazolopyrimidine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.

  本发明涉及式(I)的IRAK4的吡唑吡咯啉抑制剂，并提供包含这种抑制剂的组合物，以及用于治疗IRAK4介导或相关疾病或病症的方法。
• Hetrocyclic compounds that are inhibitors of the enzyme DPP-IV
  申请人：——

  公开号：US20030199528A1

  公开（公告）日：2003-10-23

  The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV, pharmaceutical compositions comprising the compounds and the use of such compounds for and the manufacture of medicaments for treating diseases that are associated with proteins that are subject to inactivation by DPP-IV, such as type 2 diabetes and obesity. The present inhibitors are novel purine derivatives, attached at position 8 of the purine skeleton to a diamine.

  本发明涉及治疗活性和选择性抑制酶DPP-IV的化合物，包括药物组合物和利用这些化合物制造用于治疗与受DPP-IV失活的蛋白质相关的疾病的药物，如2型糖尿病和肥胖症。本发明的抑制剂是新颖的嘌呤衍生物，在嘌呤骨架的位置8处连接到二胺。
• Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl -piperidin-1-yl)-1-propanol compounds
  申请人：DSM CATALYTICA PHARMACEUTICALS, INC.

  公开号：US20030144521A1

  公开（公告）日：2003-07-31

  The present invention provides a process for the preparation of a nonracemic diastereomer of 1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol by hydrogenation of a corresponding nonracemic 1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanone using a catalyst system comprising ruthenium, a nonracemic diphosphine ligand, a bidentate amine ligand selected from amino-thioethers and achiral diamines, and a base.

  本发明提供了一种制备非外消旋对映体1-(4-苯氧基苯基)-2-(4-羟基-4-苯基哌啶-1-基)-1-丙醇的方法，通过使用催化剂体系对相应的非外消旋1-(4-苯氧基苯基)-2-(4-羟基-4-苯基哌啶-1-基)-1-丙酮进行加氢反应，所述催化剂体系包括钌、非外消旋二膦配体、从氨基硫醚和非手性二胺中选择的双齿胺配体以及碱。
• Ethylenediamine derivatives
  申请人：——

  公开号：US20040122063A1

  公开（公告）日：2004-06-24

  The invention relates a compound represented by the formula (1): Q 1 -Q 2 -C(═O)—N(R 1 )-Q 3 -N(R 2 )-T 1 -Q 4 ( 1 ) wherein R 1 and R 2 represent H or the like; Q 1 represents an aromatic ring, heterocyclic ring or the like; Q 2 represents a single bond, aromatic ring, heterocyclic ring or the like; Q 3 represents a group 1 or the like, Q 4 represents an aromatic ring, heterocyclic ring or the like; and T 1 represents —CO— or —SO 2 —, and a medicine which comprises the compound and is useful for thrombosis and embolism.

  本发明涉及一种由式（1）表示的化合物：Q1-Q2-C(═O)—N(R1)-Q3-N(R2)-T1-Q4(1)，其中R1和R2代表H或类似物；Q1代表芳香环，杂环或类似物；Q2代表单键，芳香环，杂环或类似物；Q3代表群1或类似物，Q4代表芳香环，杂环或类似物；T1代表—CO—或—SO2—，以及包含该化合物并对治疗血栓和栓塞有用的药物。
• Monoacylated 1,2-diaminocycloalkanes
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP2431370A1

  公开（公告）日：2012-03-21

  Compounds represented by the following general formula (9): The compounds (9) are synthetic intermediates of pharmacologically active products.

  以下通式(9)所代表的化合物： 化合物（9）是药理活性产品的合成中间体。