1,3,5-环庚三烯-1-醇,2-氯-7-甲氧基- | 84519-42-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 蒽环类药物
• 中文名称: 1,3,5-环庚三烯-1-醇,2-氯-7-甲氧基-
• 英文名称: 9-Deoxydoxorubicin
• 英文别名: (8R,10S)-10-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,11-dihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione
• CAS: 84519-42-6
• 化学式: C₂₇H₂₉NO₁₀
• 分子量: 527.5
• InChiKey: KXAYNEKSZHDBGO-LOGLVVABSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  38
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  186
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• ANTI-CANCER PHOSPHONATE ANALOGS
  申请人：Boojamra Constantine G.

  公开号：US20100022467A1

  公开（公告）日：2010-01-28

  The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及磷取代的抗癌化合物、含有这些化合物的组合物以及包括给予这些化合物的治疗方法，还涉及用于制备这些化合物的过程和中间体。
• Platinum-containing compounds, and related compositions and uses thereof
  申请人：Massachusetts Institute of Technology

  公开号：US11203608B2

  公开（公告）日：2021-12-21

  Platinum-containing compounds are generally described. For example, compounds of Formula (II) are generally described. Inventive compositions and uses thereof are also described. For example, methods of treating cancer in a subject comprising administering to the subject a therapeutically effective amount of a compound of Formula (II) are generally described.

  含铂化合物一般都有描述。例如，一般描述了式（II）化合物。还描述了其发明组合物和用途。例如，一般描述了治疗受试者癌症的方法，包括向受试者施用治疗有效量的式（II）化合物。
• PLATINUM-CONTAINING COMPOUNDS, AND RELATED COMPOSITIONS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20200331942A1

  公开（公告）日：2020-10-22

  Platinum-containing compounds are generally described. Inventive compositions and uses thereof are also described.
• US7452901B2
  申请人：——

  公开号：US7452901B2

  公开（公告）日：2008-11-18
• US7645747B2
  申请人：——

  公开号：US7645747B2

  公开（公告）日：2010-01-12