2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]-1H-quinazolin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]-1H-quinazolin-4-one
• 英文别名: 2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]-3H-quinazolin-4-one
• 化学式: C₁₉H₁₅N₃O
• 分子量: 301.3
• InChiKey: UWMJPIRPHSUNGN-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  57.2
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• Fused Heterocyclic Compounds and Their Use as Sirtuin Modulators
  申请人：Milburn Michael

  公开号：US20090143376A1

  公开（公告）日：2009-06-04

  Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, chemotherapeutic induced neuropathy, neuropathy associated with an ischemic event, polyglutamine diseases, ocular diseases and/or disorders, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
• Therapeutic compounds and related methods of use
  申请人：Huber L. Julie

  公开号：US20100168084A1

  公开（公告）日：2010-07-01

  Methods of using compounds that are HAT inhibitors are described herein.
• US7998974B2
  申请人：——

  公开号：US7998974B2

  公开（公告）日：2011-08-16