4-Methoxy-N'-(3,6,8-tetramethyl-1-oxo-3,4-dihydronaphthalen-2(1H)-ylidene)benzohydrazide

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 4-Methoxy-N'-(3,6,8-tetramethyl-1-oxo-3,4-dihydronaphthalen-2(1H)-ylidene)benzohydrazide
• 英文别名: 4-methoxy-N-[(Z)-(3,3,6,8-tetramethyl-1-oxo-4H-naphthalen-2-ylidene)amino]benzamide
• 化学式: C₂₂H₂₄N₂O₃
• 分子量: 364.4
• InChiKey: JLXKWJGTZIPHBG-BSYVCWPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  67.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• GAIN-OF-FUNCTION BCL-2 INHIBITORS
  申请人：HOCKENBERY David

  公开号：US20120252839A1

  公开（公告）日：2012-10-04

  Compounds are described that are useful for treating an apoptosis-associated disease, which are specifically cytotoxic to tumor cells that are overexpressing Bcl-x L , and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-x L . Also described is a method for treating an apoptosis-associated disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an active compound that is specifically cytotoxic to tumor cells that are overexpressing Bcl-x L , and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-x L . Several scaffolds of active compounds are described.
• US8865901B2
  申请人：——

  公开号：US8865901B2

  公开（公告）日：2014-10-21
• [EN] METHOD OF INHIBITING BCL-2-RELATED SURVIVAL PROTEINS<br/>[FR] PROCÉDÉ DESTINÉ À INHIBER DES PROTÉINES DE SURVIE APPARENTÉES AUX BCL-2
  申请人：HUTCHINSON FRED CANCER RES

  公开号：WO2011041731A2

  公开（公告）日：2011-04-07

  A method for treating an apoptosis-associated disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an active compound that is specifically cytotoxic to tumor cells that are overexpressing Bcl-xL, and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-xL. Several scaffolds of active compounds are described.