1,4-二(1-氧代十二烷基)哌嗪 | 6626-83-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 1,4-二(1-氧代十二烷基)哌嗪
• 英文名称: 1,4-dilauroyl-piperazine
• 英文别名: 1,4-Dilauroyl-piperazin；1,4-bis(1-oxododecyl)piperazine；1-(4-dodecanoylpiperazin-1-yl)dodecan-1-one
• CAS: 6626-83-1
• 化学式: C₂₈H₅₄N₂O₂
• 分子量: 450.749
• InChiKey: IGWXRAMPNLUISR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  32
• 可旋转键数：
  20
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933599090

反应信息

• 作为产物：
  描述：

  哌嗪 、 月桂酸 生成 1,4-二(1-氧代十二烷基)哌嗪
  参考文献：
  名称：

  聚酰胺消泡剂。一，化学成分与有效性之间的关系

  摘要：

  DOI：

  10.1021/j150460a004

文献信息

• Transdermal compositions of 1-oxohydrocarbyl-substituted azacyclohexanes
  申请人：Whitby, Inc.

  公开号：US05073544A1

  公开（公告）日：1991-12-17

  This invention provides compositions for enhancing penetration of physiologically active agents through the skin or mucosal membranes and for retaining these agents in body tissues, said composition comprising effective amounts of a physiologically-active agent and a compound represented by the general formula ##STR1## wherein X may represent sulfur, oxygen or nitrogen; a and b may be 0 or 1, c may be 0, 1 or 2, except that when X is oxygen, a, b and c are 0, when X is nitrogen c is 0 and only one of a or b is 1, and when X is sulfur a and b are 0; A is a branched or a straight chain, divalent aliphatic radical having from 0 to 2 double bonds; R' is selected from the group consisting of H, a lower alkyl group having from 1 to 4 carbon atoms, phenyl, lower alkyl or halogen substituted phenyl, acetamido, halogen, piperidinyl, lower alkyl or halogen substituted piperidinyl, carbalkoxy, carboxamide, and alkanoyl; and R is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms, ##STR2## wherein R" is H or halogen, and salts, e.g. acid or quaternary derivatives, thereof. These compositions are useful in topical or transdermal applications of the physiologically-active agent.

  这项发明提供了用于增强生理活性剂穿透皮肤或黏膜膜并在体内组织中保留这些剂量的组合物，所述组合物包括生理活性剂和由一般式##STR1##表示的化合物的有效量，其中X可以代表硫、氧或氮；a和b可以是0或1，c可以是0、1或2，但当X为氧时，a、b和c都为0，当X为氮时，c为0，a或b中只有一个为1，当X为硫时，a和b都为0；A是具有0到2个双键的支链或直链的二价脂肪族基；R'选自H、具有1到4个碳原子的低烷基基团、苯基、低烷基或卤代苯基、乙酰胺基、卤素、哌啶基、低烷基或卤代哌啶基、羰基醇酯、羧酰胺和烷酰；R为氢或具有1到4个碳原子的低烷基基团，##STR2##其中R"为H或卤素，以及其盐，例如酸性或季铵衍生物。这些组合物在生理活性剂的局部或经皮应用中是有用的。
• 1-Oxohydrocarbyl-substituted azacyclohexanes compositions used as acid catalyst
  申请人：WHITBY RESEARCH, Inc.

  公开号：EP0582065A1

  公开（公告）日：1994-02-09

  This invention provides a process for the conversion of a reactant into a reaction product in the presence of an acid catalyst which comprises contacting said reactant with an acid catalyst comprising a compound represented by the general formula wherein X may represent sulfur, oxygen or nitrogen; a and b may be 0 or 1, c may be 0,1 or 2, except that when X is oxygen, a, b and c are O, when X is nitrogen c is 0 and only one of a or b is 1, and when X is sulfur a and b are 0; A is a branched or a straight chain, divalent aliphatic radical having from 0 to 2 double bonds; R' is selected from the group consisting of H, a lower alkyl group having from 1 to 4 carbon atoms, phenyl, lower alkyl or halogen substituted phenyl, acetamido, halogen, piperidinyl, lower alkyl or halogen substituted piperidinyl, carbalkoxy, carboxamide, and alkanoyl; and R is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms, wherein R'' is H or halogen, and salts thereof, and Z is selected from the group consisting of anions of strong acids.

  本发明提供了一种在酸催化剂存在下将反应物转化为反应产物的工艺，该工艺包括将所述反应物与酸催化剂接触，酸催化剂由通式所代表的化合物组成。 其中 X 可以代表硫、氧或氮；a 和 b 可以是 0 或 1，c 可以是 0、1 或 2，但当 X 是氧时，a、b 和 c 是 O，当 X 是氮时，c 是 0，a 或 b 中只有一个是 1，当 X 是硫时，a 和 b 是 0；A 是支链或直链二价脂族基，具有 0 至 2 个双键；R'选自由 H、具有 1 至 4 个碳原子的低级烷基、苯基、低级烷基或卤素取代的苯基、乙酰氨基、卤素、哌啶基、低级烷基或卤素取代的哌啶基、碳烷氧基、羧酰胺和烷酰基组成的组；以及 R 为氢或具有 1 至 4 个碳原子的低级烷基、 其中 R''是氢或卤素，以及它们的盐，Z 选自强酸阴离子组成的组。
• Ragon; Bolle, Memorial des services chimiques de l'Etat, 1948, vol. 34, p. 337,340
  作者：Ragon、Bolle

  DOI：——

  日期：——
• EP0280703A4
  申请人：——

  公开号：EP0280703A4

  公开（公告）日：1990-01-08
• COMPOSITIONS COMPRISING 1-OXOHYDROCARBYL-SUBSTITUTED AZACYCLOHEXANES AND THEIR USES
  申请人：Whitby Research Incorporated

  公开号：EP0280703A1

  公开（公告）日：1988-09-07