1,4-二氢蝶啶 | 25911-72-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 中文名称: 1,4-二氢蝶啶
• 英文名称: 3,4-Dihydropteridin
• 英文别名: 1,4-Dihydropteridine
• CAS: 25911-72-2
• 化学式: C₆H₆N₄
• mdl: MFCD15144321
• 分子量: 134.14
• InChiKey: JBNBYKWDFWNCFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS<br/>[FR] INHIBITEURS DE LA PROTEINE KINASE HETEROBICYCLIQUES A SUBSTITUTION DE NOYAU BICYCLIQUE 6,6
  申请人：OSI PHARM INC

  公开号：WO2005097800A1

  公开（公告）日：2005-10-20

  Compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein XI, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.

  该式(I)的化合物及其药用可接受的盐，其中XI、X2、X3、X4、X5、X6、X7、R1和Q1在此处定义，抑制IGF-1R酶，可用于治疗和/或预防高增殖性疾病，如癌症、炎症、牛皮癣、过敏/哮喘、免疫系统疾病和疾病及中枢神经系统疾病和状况。
• Imidazopyrazine tyrosine kinase inhibitors
  申请人：Beck Anne Patricia

  公开号：US20060084654A1

  公开（公告）日：2006-04-20

  Compounds of the formula and pharmaceutically acceptable salts thereof, wherein Q 1 and R 1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various diseases and conditions that respond to treatment by inhibition of tyrosine kinases.

  该式化合物及其药用盐，其中Q1和R1在此处被定义，抑制IGF-1R酶，并可用于治疗和/或预防对酪氨酸激酶抑制治疗有反应的各种疾病和症状。
• Imidazotriazines as protein kinase inhibitors
  申请人：Crew Philip Andrew

  公开号：US20060019957A1

  公开（公告）日：2006-01-26

  Compounds of the formula and pharmaceutically acceptable salts thereof, wherein Q 1 and R 1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various diseases and conditions that respond to treatment by inhibition of tyrosine kinases.

  该公式化合物及其药用可接受的盐，其中Q1和R1在此定义，抑制IGF-1R酶，并可用于治疗和/或预防对酪氨酸激酶抑制治疗有反应的各种疾病和病况。
• [EN] IMIDAZOPYRAZINOL DERIVATIVES FOR THE TREATMENT OF CANCERS<br/>[FR] DÉRIVÉS D'IMIDAZOPYRAZINOL POUR LE TRAITEMENT DES CANCERS
  申请人：OSI PHARM INC

  公开号：WO2009091939A1

  公开（公告）日：2009-07-23

  Compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-IR enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.

  化合物的结构式（I）及其药用盐，其中X1、X2、X3、X4、X5、X6、X7、R1和Q1在此处定义，抑制IGF-IR酶，可用于治疗和/或预防高增殖性疾病，如癌症、炎症、牛皮癣、过敏/哮喘、免疫系统疾病和疾病以及中枢神经系统疾病和病况。
• 6,6-Bicyclic ring substituted sulfur containing heterobicyclic protein kinase inhibitors
  申请人：Ji Qun-Sheng

  公开号：US20070032512A1

  公开（公告）日：2007-02-08

  Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X 1 , X 2 , X 3 , and Q 1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.

  该式化合物及其药用可接受盐，其中X1、X2、X3和Q1的定义如本文所述，可抑制IGF-1R酶，并用于治疗和/或预防增生性疾病，如癌症、炎症、牛皮癣、过敏/哮喘、免疫系统疾病和病症以及中枢神经系统疾病和病症。