1,4-二氨基丁烷-2,2,3,3-d4二盐酸盐 | 88972-24-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1,4-二氨基丁烷-2,2,3,3-d4二盐酸盐
• 中文别名: 腐胺-2,2,3,3-D4二盐酸盐
• 英文名称: 1,4-Butane-2,2,3,3-D4-diamine 2hcl
• 英文别名: 2,2,3,3-tetradeuteriobutane-1,4-diamine;dihydrochloride
• CAS: 88972-24-1
• 化学式: C4H14Cl2N2
• 分子量: 165.1
• InChiKey: XXWCODXIQWIHQN-RIZDZYNXSA-N

物化性质

• 熔点：
  280 °C (dec.)(lit.)
• 溶解度：
  甲醇（微溶）、水（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  0.53
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  4
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• WGK Germany：
  1

反应信息

• 作为反应物：
  描述：

  1,4-二氨基丁烷-2,2,3,3-d4二盐酸盐 生成 (1R,4Z,6R,7R,11R,12S,17R)-1,11,12,16,16-pentadeuterio-4-ethylidene-7,12-dihydroxy-6,7-dimethyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadecane-3,8-dione
  参考文献：
  名称：

  KELLY, HENRY A.;ROBINS, DAVID J., J. CHEM. SOC. PERKIN TRANS.,(1987) N 10, 2195-2202

  摘要：

  DOI：

文献信息

• KELLY, HENRY A.;ROBINS, DAVID J., J. CHEM. SOC. PERKIN TRANS.,(1987) N 10, 2195-2202
  作者：KELLY, HENRY A.、ROBINS, DAVID J.

  DOI：——

  日期：——
• Means and Methods to Diagnose Liver Toxicity using Putrescine as Biomarker
  申请人：The United States of America as represented by the Secretary of Department of Health and Human Servi

  公开号：US20140178358A1

  公开（公告）日：2014-06-26

  The present invention concerns means and methods for predicting the risk of a subject to suffer from liver damage. In particular, it pertains to a method for predicting the risk of a subject to suffer from liver damage caused by acetaminophen comprising determining the amount of putrescine in a blood, serum or plasma sample that has been obtained from the subject after administration of acetaminophen, and comparing the determined amount to a reference, whereby the risk of the subject to suffer from liver damage caused by acetaminophen is predicted. Also provided are devices for carrying out the aforementioned methods.
• MEANS AND METHODS TO DIAGNOSE LIVER TOXICITY USING PUTRESCINE AS BIOMARKER
  申请人：Metanomics Health GmbH

  公开号：US20170176477A1

  公开（公告）日：2017-06-22

  The present invention concerns means and methods for predicting the risk of a subject to suffer from liver damage. In particular, it pertains to a method for predicting the risk of a subject to suffer from liver damage caused by acetaminophen comprising determining the amount of putrescine in a blood, serum or plasma sample that has been obtained from the subject after administration of acetaminophen, and comparing the determined amount to a reference, whereby the risk of the subject to suffer from liver damage caused by acetaminophen is predicted. Also provided are devices for carrying out the aforementioned methods.
• US9673030B2
  申请人：——

  公开号：US9673030B2

  公开（公告）日：2017-06-06