1,4-二甲基哌嗪盐酸盐 | 60984-44-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 1,4-二甲基哌嗪盐酸盐
• 英文名称: 1,4-dimethylpiperazine hydrochloride
• 英文别名: 1,4-Dimethylpiperazine;hydrochloride
• CAS: 60984-44-3
• 化学式: C₆H₁₅N₂*Cl
• 分子量: 150.651
• InChiKey: ABBPJRTZWOABKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.29
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,4-二甲基哌嗪盐酸盐 、 copper(II) choride dihydrate 在 HBr 作用下， 以 甲醇 为溶剂， 生成 N,N'-dimethylpiperazinium trichlorobromocuprate
  参考文献：
  名称：

  Spectroscopic investigation on tetrahalo- and mixed-tetrahalocuprates of the N-methylpiperidinium and N,N′-dimethylpiperazinium cations

  摘要：

  DOI：

  10.1016/s0020-1693(00)94675-9
• 作为产物：
  描述：

  1,4-二甲基哌嗪 、 (4S,5R)-3-benzoyl-2-(3,4-dimethoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid 、 2-氯-4,6-二甲氧基-1,3,5-三嗪 以 甲苯 为溶剂， 反应 12.5h， 以100%的产率得到1,4-二甲基哌嗪盐酸盐
  参考文献：
  名称：

  [EN] THE METHOD FOR PRODUCTION OF SEMI-FINISHED PRODUCTS USEFUL IN SYNTHESIS OF PACLITAXEL
  [FR] PROCEDE DE PRODUCTION DE PRODUITS SEMI-FINIS UTILES DANS LA SYNTHESE DU PACLITAXEL

  摘要：

  生产半成品，用于合成通式（2）的紫杉醇的方法，其特征在于将苯基异丝氨酸衍生物或其在碳2'上具有不同构型的表异构体混合物或其盐与三嗪类缩合剂在无水有机溶剂中处理，可能在三级胺的存在下进行，并将产生的三嗪酯在无水有机溶剂中处理，可能在催化剂的存在下，与紫杉醇III处理。

  公开号：

  WO2004056790A1

文献信息

• POLYMERIZATION CATALYST FOR POLYTHIOURETHANE OPTICAL MATERIAL, POLYMERIZABLE COMPOSITION CONTAINING THE CATALYST, POLYTHIOURETHANE RESIN OBTAINED FROM THE COMPOSITION, AND METHOD FOR PRODUCING THE RESIN
  申请人：Mitsui Chemicals, Inc.

  公开号：EP2065414A1

  公开（公告）日：2009-06-03

  By using an amine hydrochloride represented by the formula (1) as a catalyst, a polythiourethane resin which is suitably used for a transparent resin for optical use, can be obtained without using an organotin compound which has been conventionally used as a catalyst for polythiourethane resins and without being affected by the acidity of an additive: wherein R1, R2 and R3 independently represent a monovalent or higher valent linear aliphatic, branched aliphatic, cyclic aliphatic or aromatic organic residue which may have a hydroxyl group or an amino group; and R1, R2 and R3 may be arbitrarily bonded to each other to form a ring.

  使用由式（1）表示的胺盐酸盐作为催化剂，可以获得一种适合用于光学用透明树脂 的聚硫氨酸树脂，而无需使用传统上用作聚硫氨酸树脂催化剂的有机锡化合物，也不会 受到添加剂酸性的影响： 其中 R1、R2 和 R3 独立地代表一价或更高价的线性脂肪族、支链脂肪族、环状脂肪族或芳香族有机残基，可带有羟基或氨基；R1、R2 和 R3 可任意地相互键合以形成环。
• POLYMERIZATION CATALYST FOR POLYTHIOURETHANE OPTICAL MATERIAL, POLYMERIZABLE COMPOSITION CONTAINING THE SAME, POLYTHIOURETHANE RESIN OBTAINED FROM THE COMPOSITION, AND PROCESS FOR PRODUCING THE RESIN
  申请人：Kawato Nobuo

  公开号：US20100029890A1

  公开（公告）日：2010-02-04

  By using an amine hydrochloride represented by the formula (1) as a catalyst, a polythiourethane resin which is suitably used for a transparent resin for optical use, can be obtained without using an organotin compound which has been conventionally used as a catalyst for polythiourethane resins and without being affected by the acidity of an additive: wherein R 1 , R 2 and R 3 independently represent a monovalent or higher valent linear aliphatic, branched aliphatic, cyclic aliphatic or aromatic organic residue which may have a hydroxyl group or an amino group; and R 1 , R 2 and R 3 may be arbitrarily bonded to each other to form a ring.
• US8586695B2
  申请人：——

  公开号：US8586695B2

  公开（公告）日：2013-11-19
• [EN] THE METHOD FOR PRODUCTION OF SEMI-FINISHED PRODUCTS USEFUL IN SYNTHESIS OF PACLITAXEL<br/>[FR] PROCEDE DE PRODUCTION DE PRODUITS SEMI-FINIS UTILES DANS LA SYNTHESE DU PACLITAXEL
  申请人：AGROPHARM S A

  公开号：WO2004056790A1

  公开（公告）日：2004-07-08

  The method for production of the semi-finished products useful in synthesis of Paclitaxel with the generalized formula (2), characterized in that phenyl isoserine derivatives, or mixtures of their epimerides with various configurations on the carbon 2' or their salts, are treated with triazine type condensing agent, possible in the presence of tertiary amine, in medium of anhydrous organic solvent, and the triazine esters produced are treated with Baccatin III, in medium of anhydrous organic solvent, possible in the presence of a catalyst.

  生产半成品，用于合成通式（2）的紫杉醇的方法，其特征在于将苯基异丝氨酸衍生物或其在碳2'上具有不同构型的表异构体混合物或其盐与三嗪类缩合剂在无水有机溶剂中处理，可能在三级胺的存在下进行，并将产生的三嗪酯在无水有机溶剂中处理，可能在催化剂的存在下，与紫杉醇III处理。
• Spectroscopic investigation on tetrahalo- and mixed-tetrahalocuprates of the N-methylpiperidinium and N,N′-dimethylpiperazinium cations
  作者：Giusppe Marcotrigiano、Ledi Menabue、Gian Carlo Pellacani、Monica Saladini

  DOI：10.1016/s0020-1693(00)94675-9

  日期：1979.1