1-(1,1-二甲氧基乙基)哌啶 | 72292-84-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-(1,1-二甲氧基乙基)哌啶
• 英文名称: 1,1-dimethoxy-1-(N-piperidinyl)ethane
• 英文别名: 1-(1,1-Dimethoxyethyl)piperidine
• CAS: 72292-84-3
• 化学式: C₉H₁₉NO₂
• 分子量: 173.255
• InChiKey: IDVSPMSVJFTGRS-UHFFFAOYSA-N

物化性质

• 沸点：
  194.5±30.0 °C(Predicted)
• 密度：
  0.981±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(1,1-二甲氧基乙基)哌啶 在 一水合肼 作用下， 生成 [1-Piperidin-1-yl-eth-(E)-ylidene]-hydrazine
  参考文献：
  名称：

  Bruzzese; Cedro; Dell'Acqua, Farmaco, Edizione Scientifica, 1986, vol. 41, # 3, p. 196 - 204

  摘要：

  DOI：
• 作为产物：
  描述：

  1-乙酰哌啶 、 sodium methylate 、 硫酸二甲酯 以 Petroleum ether 为溶剂， 反应 4.5h， 生成 1-(1,1-二甲氧基乙基)哌啶
  参考文献：
  名称：

  Design, synthesis and anti-tumoractivity of novel amidine derivatives of doxifluridine

  摘要：

  A series of novel amidine derivatives of doxifluridine were synthesized using acid amide as the starting material, and their antitumor activity was evaluated in A549 cells. Compounds 10 and 11 demonstrated were more potent than 5-Fu, which was used as a positive control. Compound 10, which were found to be the most potent one with IC50 of 3.2 mu mol/L, was 16 times more potent than 5-Fu with IC50 of 52 mu mol/L to the A549 cells. A new route was designed to synthesize 5'-deoxy-5-fluorocytidine. All compounds were characterized by H-1 NMR, MS and X-ray spectras in detail. (C) 2009 K. Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2009.10.013

文献信息

• Ahuja; Singh; Asthana, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1989, vol. 28, # 12, p. 1034 - 1038
  作者：Ahuja、Singh、Asthana、Sardana、Anand

  DOI：——

  日期：——
• Jotwani, Padma; Singh, Jujhar; Anand, Nitya, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1987, vol. 26, # 1-12, p. 1039 - 1041
  作者：Jotwani, Padma、Singh, Jujhar、Anand, Nitya

  DOI：——

  日期：——
• Ahuja, Padma; Singh, Jujhar; Anand, Nitya, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1983, vol. 22, # 11, p. 1087 - 1089
  作者：Ahuja, Padma、Singh, Jujhar、Anand, Nitya

  DOI：——

  日期：——
• AHUJA, PADMA;SINGH, JUJHAR;ASTHANA, M. B.;SARDANA, VINOD;ANAND, NITYA, INDIAN. J. CHEM. B , 28,(1989) N2, C. 1034-1038
  作者：AHUJA, PADMA、SINGH, JUJHAR、ASTHANA, M. B.、SARDANA, VINOD、ANAND, NITYA

  DOI：——

  日期：——
• AHUJA, P.;SINGH, J.;ANAND, N., INDIAN J. CHEM., 1983, 22, N 11, 1087-1089
  作者：AHUJA, P.、SINGH, J.、ANAND, N.

  DOI：——

  日期：——