曙红双乙酸酯 | 7284-92-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 曙红双乙酸酯
• 英文名称: (6'-acetoxy-2′,4′,5′,7′-tetrabromo-3-oxo-spiro[isobenzofuran-1,9′-xanthene]-3′-yl) acetate
• 英文别名: eosin Y diacetate；3',6'-diacetoxy-2',4',5',7'-tetrabromo-spiro[phthalan-1,9'-xanthen]-3-one；3',6'-Diacetoxy-2',4',5',7'-tetrabrom-spiro[phthalan-1,9'-xanthen]-3-on；Eosin diacetate；(6'-acetyloxy-2',4',5',7'-tetrabromo-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl) acetate
• CAS: 7284-92-6
• 化学式: C₂₄H₁₂Br₄O₇
• 分子量: 731.971
• InChiKey: ADWIDTFZSUABGT-UHFFFAOYSA-N

物化性质

• 溶解度：
  在DMF中可溶

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  88.1
• 氢给体数：
  0
• 氢受体数：
  7

安全信息

• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  曙红双乙酸酯 、 sodium thiomethoxide 在 四(三苯基膦)钯 、 sodium hydroxide 、 盐酸 作用下， 生成
  参考文献：
  名称：

  COLORIMETRIC DETERMINATION OF AQUEOUS NITRATE CONCENTRATION

  摘要：

  测量水样中硝酸盐浓度的方法包括将水样与一种含有色团基团的水溶性硫醚化合物在水溶性催化剂存在下混合；测量颜色变化，并将颜色变化与硝酸盐浓度相关联。

  公开号：

  US20180031535A1
• 作为产物：
  描述：

  荧光素 在 溴 、 溶剂黄146 作用下， 生成 曙红双乙酸酯
  参考文献：
  名称：

  Baeyer, Justus Liebigs Annalen der Chemie, 1876, vol. 183, p. 31

  摘要：

  DOI：

文献信息

• Encrypted optical markers for security applications
  申请人：APDN (B.V.I.) INC.

  公开号：US10745825B2

  公开（公告）日：2020-08-18

  Encrypted markers that are not readily detectable can be revealed by treatment with a specific reagent used as a developer to reveal a readily detectable physical property of the marker, such as a characteristic fluorescence emission after excitation with a particular excitation wavelength, or to reveal a visible color. The encrypted marker can be developed in situ, or a sample can be removed by brushing, scraping, swabbing or scratching the marked object or item and developing the encrypted marker or a sample thereof with the appropriate developer to reveal an overt marker or optical signal. The encrypted marker may include a DNA taggant.

  不易检测的加密标记可以通过使用特定试剂处理来揭示，该试剂用作开发剂以揭示标记的易检测物理特性，例如在特定激发波长下激发后的特征荧光发射，或者揭示可见颜色。加密标记可以在原位中开发，或者可以通过刷、刮、拭或划痕标记的物体或物品来移除样品，并用适当的开发剂开发加密标记或其样品，以揭示明显的标记或光学信号。加密标记可能包括DNA标记剂。
• Electronic and Steric Optimization of Fluorogenic Probes for Biomolecular Imaging
  作者：Wen Chyan、Henry R. Kilgore、Brian Gold、Ronald T. Raines

  DOI：10.1021/acs.joc.7b00285

  日期：2017.4.21

  Fluorogenic probes are invaluable tools for spatiotemporal investigations within live cells. In common fluorogenic probes, the intrinsic fluorescence of a small-molecule fluorophore is masked by esterification until entry into a cell, where endogenous esterases catalyze the hydrolysis of the masking groups, generating fluorescence: The-susceptibility of masking groups to spontaneous hydrolysis is a major limitation of these probes. Previous attempts to address this problem have incorporated auto-immolativo linkers at the cost of atom economy and synthetic adversity. Here, we report on a linker-free strategy that employs adventitious electronic and steric interactions in easy-to-synthesize probes. We find that X center dot center dot center dot C=O n ->pi* interactions and acyl group size are optimized in 2 ',7 '-dichlorofluorescein diisobutyrate. This probe is relatively stable to spontaneous hydrolysis but is a highly reactive substrate for esterases both in vitro and in cellulo, yielding a bright, photostable fluorophore with utility in biomolecular imaging.
• Meyer,R.; Pfotenhauer, Chemische Berichte, 1905, vol. 38, p. 3962
  作者：Meyer,R.、Pfotenhauer

  DOI：——

  日期：——
• Dolinsky; Jones, Journal of the Association of Official Agricultural Chemists, 1951, vol. 34, p. 114,115
  作者：Dolinsky、Jones

  DOI：——

  日期：——
• Sah; Yen, Science Reports of National Tsing Hua University, Series A: Mathematical, Physical, and Engineering Sciences, 1932, vol. <A> 1, p. 269,274
  作者：Sah、Yen

  DOI：——

  日期：——