(2Z)-3-(3-bromo-4-hydroxy-phenyl)-N-[2-[2-[[(2Z)-3-(3-bromo-4-hydroxy-phenyl)-2-hydroxyimino-propanoyl]amino]ethyldisulfanyl]ethyl]-2-hydroxyimino-propanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (2Z)-3-(3-bromo-4-hydroxy-phenyl)-N-[2-[2-[[(2Z)-3-(3-bromo-4-hydroxy-phenyl)-2-hydroxyimino-propanoyl]amino]ethyldisulfanyl]ethyl]-2-hydroxyimino-propanamide
• 英文别名: (2Z)-3-(3-bromo-4-hydroxyphenyl)-N-[2-[2-[[(2Z)-3-(3-bromo-4-hydroxyphenyl)-2-hydroxyiminopropanoyl]amino]ethyldisulfanyl]ethyl]-2-hydroxyiminopropanamide
• 化学式: C₂₂H₂₄Br₂N₄O₆S₂
• 分子量: 664.4
• InChiKey: LMAFSGDNHVBIHU-HJTNQMAYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  36
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  214
• 氢给体数：
  6
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  (2Z)-3-(3-bromo-4-hydroxy-phenyl)-N-[2-[2-[[(2Z)-3-(3-bromo-4-hydroxy-phenyl)-2-hydroxyimino-propanoyl]amino]ethyldisulfanyl]ethyl]-2-hydroxyimino-propanamide 、 碘甲烷 生成 (2Z)-3-(3-bromo-4-methoxyphenyl)-N-[2-[2-[[(2Z)-3-(3-bromo-4-methoxyphenyl)-2-methoxyiminopropanoyl]amino]ethyldisulfanyl]ethyl]-2-methoxyiminopropanamide
  参考文献：
  名称：

  RODRIGUEZ, A. D.;AKEE, RHONE K.;SCHEUER, PAUL J., TETRAHEDRON LETT., 28,(1987) N 42, 4989-4992

  摘要：

  DOI：

文献信息

• QUINOA, EMILIO;CREWS, PHILLIP, TETRAHEDRON LETT., 28,(1987) N 28, 3229-3232
  作者：QUINOA, EMILIO、CREWS, PHILLIP

  DOI：——

  日期：——
• METHOD OF SENSITIZING CANCER CELLS TO THE CYTOTOXIC EFFECTS OF DEATH RECEPTOR LIGANDS IN CANCER TREATMENT
  申请人：Sayers Thomas Joseph

  公开号：US20130039883A1

  公开（公告）日：2013-02-14

  Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with a death receptor ligand, which method comprises contacting the cancer cells with a death receptor ligand in conjunction with an effective amount of a compound described herein, for example, a cucurbitacin (I) or a withanolide (II). Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with a compound described herein, for example, a cucurbitacin (I) or a withanolide (II) and also contacting the cancer cells with a death receptor ligand, whereby apoptosis is induced in the cancer cells.
• PSAMMAPLIN A FOR MODULATING IDO EXPRESSION
  申请人：IDOGEN AB

  公开号：US20210299069A1

  公开（公告）日：2021-09-30

  The present invention relates to ex vivo methods using psammaplin A, the compound of formula (I) and related uses.
• US9238069B2
  申请人：——

  公开号：US9238069B2

  公开（公告）日：2016-01-19
• [EN] METHOD OF SENSITIZING CANCER CELLS TO THE CYTOTOXIC EFFECTS OF DEATH RECEPTOR LIGANDS IN CANCER TREATMENT<br/>[FR] PROCÉDÉ DE SENSIBILISATION DE CELLULES CANCÉREUSES AUX EFFETS CYTOTOXIQUES DE LIGANDS DES RÉCEPTEURS DE MORT DANS LE TRAITEMENT DU CANCER
  申请人：US HEALTH

  公开号：WO2011084623A1

  公开（公告）日：2011-07-14

  Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with a death receptor ligand, which method comprises contacting the cancer cells with a death receptor ligand in conjunction with an effective amount of a compound described herein, for example, a cucurbitacin (I) or a withanolide (II). Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with a compound described herein, for example, a cucurbitacin (I) or a withanolide (II) and also contacting the cancer cells with a death receptor ligand, whereby apoptosis is induced in the cancer cells.