1-(3-甲氧基-4-亚硝基苯基)哌啶 | 1032716-21-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-(3-甲氧基-4-亚硝基苯基)哌啶
• 英文名称: 1-(3-methoxy-4-nitrosophenyl)piperidine
• CAS: 1032716-21-4
• 化学式: C₁₂H₁₆N₂O₂
• 分子量: 220.271
• InChiKey: LBRAOYXCERFEHP-UHFFFAOYSA-N

物化性质

• 沸点：
  383.1±37.0 °C(Predicted)
• 密度：
  1.17±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(3-甲氧基-4-亚硝基苯基)哌啶 在 盐酸 作用下， 以 乙醚 、 乙醇 为溶剂， 生成 C₁₂H₁₆N₂O₂*ClH
  参考文献：
  名称：

  Synthesis and in Vitro Antiprotozoal Activities of Water-Soluble, Inexpensive 3,7-Bis(dialkylamino)phenoxazin-5-ium Derivatives

  摘要：

  3,7-Bis(dialkylamino)phenoxazinium salts were synthesized and evaluated for in vitro activities against Plasmodium falciparum, Trypanosoma cruzi, T. brucei rhodesiense, and Leishmania donovani. Notably, the compounds showed potent antiprotozoal activities, especially against P. falciparum and T cruzi. The compounds with alkyl side chains less than three carbons in length possessed good activities with high selective indices.

  DOI：

  10.1021/jm8003619
• 作为产物：
  描述：

  1,5-二氯戊烷 在 盐酸 、 sodium hydride 、 sodium nitrite 作用下， 以 四氢呋喃 、 水 、 甲苯 、 mineral oil 为溶剂， 反应 51.17h， 生成 1-(3-甲氧基-4-亚硝基苯基)哌啶
  参考文献：
  名称：

  [EN] NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION
  [FR] FORMULATIONS DE FLUOROPHORE SPÉCIFIQUE AUX NERFS POUR ADMINISTRATION DIRECTE ET SYSTÉMIQUE

  摘要：

  描述了用于直接或全身给药的神经特异性荧光素配方。这些配方可用于荧光引导手术（FGS），帮助在外科手术干预期间保护神经。

  公开号：

  WO2020033435A1

文献信息

• [EN] NEAR-INFRARED NERVE-SPARING FLUOROPHORES<br/>[FR] FLUOROPHORES ÉPARGNANT LES NERFS EN PROCHE INFRAROUGE
  申请人：UNIV OREGON HEALTH & SCIENCE

  公开号：WO2020023911A3

  公开（公告）日：2020-03-26
• Third-order nonlinear optical properties of a new type of D–π–D unsymmetrical phenoxazinium chloride with resonance structures
  作者：Jian-Feng Ge、Yue-Ting Lu、Qing-Feng Xu、Wu Liu、Na-Jun Li、Ru Sun、Ying-Lin Song、Jian-Mei Lu

  DOI：10.1016/j.chemphys.2011.02.013

  日期：2011.4

  A new series of unsymmetrical phenoxazinium chlorides, featuring a heterocyclic aromatic pi-bridge with dialkylamino donors, were evaluated in acetonitrile solution for third-order nonlinear optical properties at 532 nm using a Z-scan technique. The title compounds exhibit strong reverse saturable absorption and nonlinear refraction. The third-order nonlinear optical properties were obtained under nanosecond and picosecond laser beams. The nonlinear mechanism is revealed by the excited-state nonlinearity, as observed from a picosecond pump-probe response experiment for one of the compounds. They are potential nonlinear optical materials because they also have good solubility in polar solvents and good thermal stability. (C) 2011 Elsevier B. V. All rights reserved.
• NEAR-INFRARED NERVE-SPARING FLUOROPHORES
  申请人：Oregon Health & Science University

  公开号：EP3829420A2

  公开（公告）日：2021-06-09
• NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION
  申请人：Oregon Health & Science University

  公开号：EP3833401A1

  公开（公告）日：2021-06-16