1-(4-氨基-2,6-二氟苯基)-4-哌啶酮 | 565459-91-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-(4-氨基-2,6-二氟苯基)-4-哌啶酮
• 英文名称: 1-(4-amino-2,6-difluorophenyl)-4-piperidinone
• 英文别名: 1-(4-amino-2,6-difluorophenyl)piperidin-4-one
• CAS: 565459-91-8
• 化学式: C₁₁H₁₂F₂N₂O
• 分子量: 226.226
• InChiKey: BJVYWLWLSHXXOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(4-氨基-2,6-二氟苯基)-4-哌啶酮 在 盐酸 、 sodium nitrite 、 sodium azide 、 sodium acetate 作用下， 反应 1.0h， 以55%的产率得到1-(4-azido-2,6-difluorophenyl)-4-piperidinone
  参考文献：
  名称：

  [EN] TRIAZOLE DERIVATIVES AS ANTIBACTERIAL AGENTS
  [FR] NOUVEAUX COMPOSES TRIAZOLIQUES, LEUR PROCEDE DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

  摘要：

  公开号：

  WO2005035528A3
• 作为产物：
  描述：

  1-(2,6-二氟-4-硝基-苯基)-哌啶-4-酮 在 palladium on activated charcoal 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 18.0h， 生成 1-(4-氨基-2,6-二氟苯基)-4-哌啶酮
  参考文献：
  名称：

  A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials

  摘要：

  Oxazolidinone analogs bearing substituted piperidine or azetidine C-rings are described. Analogs with a methyl group at the 3-position of the azetidine ring or the 4-position of the piperidine ring exhibited reduced mitochondrial protein synthesis inhibition while retaining good antibacterial potency. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.07.022

文献信息

• NOVEL ANTIBACTERIAL COMPOUNDS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Das Jagattaran

  公开号：US20050113347A1

  公开（公告）日：2005-05-26

  The present invention relates to novel triazole compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them. More particularly, the present invention relates to novel triazoles of the general formula (I) their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

  本发明涉及一种新型三唑化合物，其化学式为（I），其衍生物，类似物，互变异构体，区域异构体，旋转异构体，立体异构体，多晶形态，药学上可接受的盐，药学上可接受的溶剂化合物以及含有它们的制药组合物。更具体地，本发明涉及一种新型三唑化合物，其一般式为（I），其衍生物，类似物，互变异构体，区域异构体，旋转异构体，立体异构体，多晶形态，药学上可接受的盐，药学上可接受的溶剂化合物以及含有它们的制药组合物。
• Novel antibacterial compounds: process for their preparation and pharmaceutical compositions containing them
  申请人：Das Jagattaran

  公开号：US20050209223A1

  公开（公告）日：2005-09-22

  The present invention relates to novel triazole compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them. More particularly, the present invention relates to novel triazoles of the general formula (I) their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

  本发明涉及公式（I）的新型三唑类化合物及其衍生物、类似物、互变异构体、区域异构体、旋转异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂化物和含有它们的制药组合物。更特别地，本发明涉及一般公式（I）的新型三唑及其衍生物、类似物、互变异构体、区域异构体、旋转异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂化物和含有它们的制药组合物。
• Antibacterial compounds: process for their preparation and pharmaceutical compositions containing them
  申请人：Dr. Reddy's Laboratories Limited

  公开号：US07202254B2

  公开（公告）日：2007-04-10

  The present invention relates to novel triazole compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them. More particularly, the present invention relates to novel triazoles of the general formula (I) their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

  本发明涉及一种新型三唑类化合物，其化学式为（I），其衍生物、类似物、互变异构体、区域异构体、旋转异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂化物以及包含它们的制药组合物。更具体地，本发明涉及一种新型三唑类化合物，其化学式为（I），其衍生物、类似物、互变异构体、区域异构体、旋转异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂化物以及包含它们的制药组合物。
• NOVEL ANTIBACTERIAL COMPOUNDS:PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：EP1467977A1

  公开（公告）日：2004-10-20
• US6914058B2
  申请人：——

  公开号：US6914058B2

  公开（公告）日：2005-07-05