4-({(E)-[4-(diethylamino)phenyl]methylidene}amino)-6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-({(E)-[4-(diethylamino)phenyl]methylidene}amino)-6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one
• 英文别名: 4-[(E)-[4-(diethylamino)phenyl]methylideneamino]-6-methyl-3-sulfanylidene-2H-1,2,4-triazin-5-one
• 化学式: C₁₅H₁₉N₅OS
• 分子量: 317.4
• InChiKey: JKNCBDOZPMOPLE-MHWRWJLKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  92.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Compositions and methods for stabilizing benzothiazole luciferin analogs
  申请人：PROMEGA CORPORATION

  公开号：US11136615B2

  公开（公告）日：2021-10-05

  Disclosed herein are compositions and methods for stabilizing a benzothiazole luciferin analog such as D-luciferin and 6-amino-D-luciferin. The compositions may include the benzothiazole luciferin analog, a thionucleobase compound of formula (I), and a liquid medium, in which the thionucleobase is present in an amount effective to stabilize the luminogenic composition against decomposition. The methods provided herein may stabilize the benzothiazole luciferin analog against decomposition by contacting the benzothiazole luciferin analog with an effective amount of the thionucleobase compound in the presence of a liquid medium. Also provided herein is a kit containing the composition.

  本文公开了稳定苯并噻唑荧光素类似物（如 D-荧光素和 6-氨基-D-荧光素）的组合物和方法。这些组合物可包括苯并噻唑荧光素类似物、式（I）的硫代核酸酯化合物和液体培养基，其中硫代核酸酯的含量可有效稳定发光组合物，防止其分解。本文提供的方法可通过在液体介质存在下使苯并噻唑荧光素类似物与有效量的硫代核酸酶化合物接触来稳定苯并噻唑荧光素类似物，防止其分解。本文还提供了一种含有该组合物的试剂盒。
• COMPOSITIONS AND METHODS FOR STABILIZING LUMINOGENIC SUBSTRATES
  申请人：Promega Corporation

  公开号：EP3146066A1

  公开（公告）日：2017-03-29
• COMPOSITIONS AND METHODS FOR STABILIZING BENZOTHIAZOLE LUCIFERIN ANALOGS
  申请人：Promega Corporation

  公开号：EP3661932B1

  公开（公告）日：2021-10-06
• COMPOSITIONS AND METHODS FOR ANALYTE DETECTION USING BIOLUMINESCENCE
  申请人：Promega Corporation

  公开号：EP3953374A1

  公开（公告）日：2022-02-16
• US9676997B2
  申请人：——

  公开号：US9676997B2

  公开（公告）日：2017-06-13