2-methyl-3-{[(E)-(5-nitrofuran-2-yl)methylidene]amino}quinazolin-4(3H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-methyl-3-{[(E)-(5-nitrofuran-2-yl)methylidene]amino}quinazolin-4(3H)-one
• 英文别名: 2-methyl-3-[(E)-(5-nitrofuran-2-yl)methylideneamino]quinazolin-4-one
• 化学式: C14H10N4O4
• 分子量: 298.25
• InChiKey: OYSNDVMJHSZSPR-OVCLIPMQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  104
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-氨基-2-甲基-4(3H)喹唑啉酮 以55%的产率得到
  参考文献：
  名称：

  ROSHDY S. M.; GHONEIM K. M.; KHALIFA M., PHARMAZIE , 1975, 30, NO 4, 210-213

  摘要：

  DOI：

文献信息

• BOCTPOBA, L. N.;GRENADEROVA, M. V.;NEDZVETSKIJ, V. S.;KONUP, I. P.;ANDREE+, XIM.-FARMATS. ZH., 23,(1989) N, S. 584-587
  作者：BOCTPOBA, L. N.、GRENADEROVA, M. V.、NEDZVETSKIJ, V. S.、KONUP, I. P.、ANDREE+

  DOI：——

  日期：——
• ANTIBIOTIC COMPOUNDS THAT INHIBIT BACTERIAL PROTEIN SYNTHESIS
  申请人：The Board of Regents of the University of Texas System

  公开号：US20160220510A1

  公开（公告）日：2016-08-04

  An aminoacylation/translation (AIT) system based on the protein synthesis system from the pathogen Pseudomonas aeruginosa , was used to screen chemical compounds for identifying inhibitors of protein synthesis. This system includes elongation factors: EF-Tu, EF-Ts and EF-G, aminoacyl tRNA synthetase (aaRS) specific for phenylalanine, PheRS, and ribosomes isolated from cultures of Pseudomonas aeruginosa . Compounds identified using this assay have been shown to contain broad spectrum activity against both Gram+ and Gram− pathogens. Methods of using the identified compounds, as well as derivatives and analogues of these compounds, as antimicrobial agents against bacterial infections are described.
• ROSHDY S. M.; GHONEIM K. M.; KHALIFA M., PHARMAZIE <PHAR-AT>, 1975, 30, NO 4, 210-213
  作者：ROSHDY S. M.、 GHONEIM K. M.、 KHALIFA M.

  DOI：——

  日期：——