4-Cyclopentylsulfanylquinazoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-Cyclopentylsulfanylquinazoline
• 化学式: C₁₃H₁₄N₂S
• 分子量: 230.33
• InChiKey: DJYXIGLJSJJBGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  51.1
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Activators of autophagic flux and phospholipase D and clearance of protein aggregates including tau and treatment of proteinopathies
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US10865214B2

  公开（公告）日：2020-12-15

  The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further discloses use of said compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, particularly proteinopathies and tauopathies such as Alzheimer's disease. It further discloses methods of enhancing autophagic flux.

  本申请公开了作为自噬通量激活剂的化合物以及包含所述激活剂的药物组合物。它进一步公开了所述化合物和药物组合物在治疗神经退行性疾病中的用途，特别是蛋白病和牛磺酸病，如阿尔茨海默病。它进一步公开了增强自噬通量的方法。
• ACTIVATORS OF AUTOPHAGIC FLUX AND PHOSPHOLIPASE D AND CLEARANCE OF PROTEIN AGGREGATES INCLUDING TAU AND TREATMENT OF PROTEINOPATHIES
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20170210759A1

  公开（公告）日：2017-07-27

  The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further discloses use of said compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, particularly proteinopathies and tauopathies such as Alzheimer's disease. It further discloses methods of enhancing autophagic flux.
• [EN] ACTIVATORS OF AUTOPHAGIC FLUX AND PHOSPHOLIPASE D AND CLEARANCE OF PROTEIN AGGREGATES INCLUDING TAU AND TREATMENT OF PROTEINOPATHIES<br/>[FR] ACTIVATEURS DE FLUX AUTOPHAGIQUE ET DE PHOSPHOLIPASE D ET CLAIRANCE D'AGRÉGATS DE PROTÉINES COMPRENANT TAU ET TRAITEMENT DE PROTÉINOPATHIES
  申请人：UNIV COLUMBIA

  公开号：WO2018067589A1

  公开（公告）日：2018-04-12

  The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further discloses use of said compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, particularly proteinopathies and tauopathies such as Alzheimer's disease. It further discloses methods of enhancing autophagic flux.