1-(环己基氨基)环己烷甲腈 | 6623-11-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1-(环己基氨基)环己烷甲腈
• 英文名称: 1-cyano-1-(cyclohexylamino)cyclohexane
• 英文别名: 1-cyclohexylamino-cyclohexanecarbonitrile；1-Cyclohexylamino-cyclohexancarbonitril；1-Cyclohexylamino-hexahydrobenzonitril；1-Cyan-dicyclohexylamin；1-(Cyclohexylamino)cyclohexanecarbonitrile；1-(cyclohexylamino)cyclohexane-1-carbonitrile
• CAS: 6623-11-6
• 化学式: C₁₃H₂₂N₂
• 分子量: 206.331
• InChiKey: OUAURGNVVSZCEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2926909090

反应信息

• 作为反应物：
  描述：

  1-(环己基氨基)环己烷甲腈 在 盐酸 、 水 作用下， 反应 18.0h， 生成 1-Cyclohexylamino-cyclohexanecarboxylic acid amide
  参考文献：
  名称：

  Oxidation of secondary amines to α-cyanoamines

  摘要：

  DOI：

  10.1016/s0040-4039(00)98440-5
• 作为产物：
  描述：

  环己胺 在 盐酸 、 sodium hydrogen sulfate 作用下， 以 水 为溶剂， 反应 25.0h， 生成 1-(环己基氨基)环己烷甲腈
  参考文献：
  名称：

  Oxidative cyanation of aminyl radicals in sodium peroxydisulfate-sodium cyanide system

  摘要：

  DOI：

  10.1007/bf00959201

文献信息

• Koetz; Merkel, Journal fur praktische Chemie (Leipzig 1954), 1926, vol. <2> 113, p. 74
  作者：Koetz、Merkel

  DOI：——

  日期：——
• Synthesis and antinociception properties of phencyclidine derivatives with modified aromatic or cycloalkyl rings and amino group
  作者：Abbas Ahmadi、Mohsen Khalili、Mahnaz Barzin、Mohsen Pooladi、Fatemeh Bakhtiari、Maede Barjeste、Babak Nahri-Niknafs

  DOI：10.1007/s00706-015-1472-1

  日期：2016.2

  Phencyclidine is an arylcyclohexylamine compound which has received a lot of investigative attention due to the complex spectrum of behaviours and its complicated interactions with the central nervous system. Phencyclidine administration may act as stimulant, depressant, hallucinogen, and analgesic depending on dose and tested species. In this study, new phenyl and thienyl analogues with specific affinity for the phencyclidine sites in NMDA receptors, dopamine uptake blocking, or both of them were synthesized. The acute and chronic pain properties of these compounds were studied using the tail immersion and formalin tests on mice and the results were compared with control and phencyclidine groups at a dose of 10 mg/kg. The outcomes indicated that all synthesized compounds showed better activities to decrease acute thermal and chemical, but not chronic pains. Also, these effects were more significant for phenyl (group 1) compared to thiophene (group 2) analogues, which is probably due to the higher affinity of group 1 for inhibition of dopamine reuptake compared to binding to the phencyclidine sites in NMDA receptors in this family.[GRAPHICS].
• BARTON, D. H. R.;BILLION, A.;BOIVIN, J., TETRAHEDRON LETT., 1985, 26, N 9, 1229-1232
  作者：BARTON, D. H. R.、BILLION, A.、BOIVIN, J.

  DOI：——

  日期：——
• TROYANSKIJ, EH. I.;IOFFE, V. A.;MIZINTSEV, V. V.;NIKISHIN, G. I., IZV. AN CCCP. CEP. XIM., 1984, N 8, 1814-1822
  作者：TROYANSKIJ, EH. I.、IOFFE, V. A.、MIZINTSEV, V. V.、NIKISHIN, G. I.

  DOI：——

  日期：——
• US4173567A
  申请人：——

  公开号：US4173567A

  公开（公告）日：1979-11-06