trans-2-Methyl-3-hydroxychinuclidin | 873558-39-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 英文名称: trans-2-Methyl-3-hydroxychinuclidin
• 英文别名: (2R,3S)-2-methyl-1-azabicyclo[2.2.2]octan-3-ol
• CAS: 873558-39-5
• 化学式: C₈H₁₅NO
• 分子量: 141.213
• InChiKey: VLJPCCPJHQAAQB-HTRCEHHLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] 3-(HETEROARYL-OXY)-2-ALKYL-1-AZA-BICYCLOALKYL DERIVATIVES AS ALPHA.7-NACHR LIGANDS FOR THE TREATMENT OF CNS DISEASES<br/>[FR] DERIVES 3-(HETEROARYL-OXY)-2-ALKYL-1-AZA-BICYCLOALKYLE UTILISES COMME LIGANDS D'ALPHA.7-NACHR POUR LE TRAITEMENT DE MALADIES DU SNC
  申请人：NOVARTIS AG

  公开号：WO2006005608A1

  公开（公告）日：2006-01-19

  The present invention relates to 1-aza-bicycloalkyl derivatives of formula (I) wherein the substituents are as defined in the specification, to processes for their production, their use as pharmaceuticals in the prevention and treatment of psychotic and neurodegenerative disorders. The claimed compounds act as nicotinic acelylcholine receptors (NACHR) ligands.

  本发明涉及式(I)的1-aza-双环脂肪环衍生物，其中取代基如规范中所定义，以及它们的制备过程，它们作为药物在预防和治疗精神病和神经退行性疾病中的使用。所述化合物作为尼古丁酸乙酰胆碱受体(NACHR)配体发挥作用。
• 3-(heteroaryl-oxy)-2-alkyl-1-aza-bicycloalkyl derivatives as alpha.7-nAChR ligands for the treatment of CNS diseases.
  申请人：Novartis AG

  公开号：EP2457911A1

  公开（公告）日：2012-05-30

  The present invention relates to 1-aza-bicycloalkyl derivatives of formula (I) wherein the substituents are as defined in the specification, to processes for their production, their use as pharmaceuticals in the prevention and treatment of psychotic and neurodegenerative disorders. The claimed compounds act as nicotinic acelylcholine receptors (NACHR) ligands.

  本发明涉及式 (I) 的 1-氮杂双环烷基衍生物 其中的取代基如说明书中所定义，并涉及其生产工艺、在预防和治疗精神病和神经退行性疾病中的药物用途。所述化合物可作为烟碱乙酰胆碱受体（NACHR）配体。
• 3-(HETEROARYL-OXY)-2-ALKYL-1-AZA-BICYCLOALKYL DERIVATIVES AS ALPHA.7-NACHR LIGANDS FOR THE TREATMENT OF CNS DISEASES.
  申请人：Novartis AG

  公开号：EP1776360B1

  公开（公告）日：2010-12-29
• 3-(Heteroaryl-Oxy)-2-Alkyl-1-Aza-Bicycloalkyl Derivatives As Alpha. 7-Nachrligands For TheTreatment Of Cns Diseases
  申请人：Feuerbach Dominik

  公开号：US20080194573A1

  公开（公告）日：2008-08-14

  The present invention relates to 1-aza-bicycloalkyl derivatives of formula (I) wherein the substituents are as defined in the specification, to processes for their production, their use as pharmaceuticals in the prevention and treatment of psychotic and neurodegenerative disorders. The claimed compounds act as nicotinic acelylcholine receptors (NACHR) ligands.
• 3-(HETEROARYL-OXY)-2-ALKYL-1-AZA-BICYCLOALKYL DERIVATIVES AS ALPHA. 7-NACHR LIGANDS FOR THE TREATMENT OF CNS DISEASES
  申请人：FEUERBACH Dominik

  公开号：US20100093746A1

  公开（公告）日：2010-04-15

  The present invention relates to 1-aza-bicycloalkyl derivatives of formula (I) wherein the substituents are as defined in the specification, to processes for their production, their use as pharmaceuticals in the prevention and treatment of psychotic and neurodegenerative disorders. The claimed compounds act as nicotinic acetylcholine receptors (NACHR) ligands.