1-[[2-[[2-[(2-氨基乙基)氨基]乙基]氨基]乙基]氨基]丙-2-醇 | 29513-72-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1-[[2-[[2-[(2-氨基乙基)氨基]乙基]氨基]乙基]氨基]丙-2-醇
• 英文名称: 1-((2-((2-((2-aminoethyl)amino)ethyl)amino)ethyl)amino)propan-2-ol
• 英文别名: 1-[2-[2-(2-aminoethylamino)ethylamino]ethylamino]propan-2-ol
• CAS: 29513-72-2
• 化学式: C₉H₂₄N₄O
• 分子量: 204.316
• InChiKey: GKCQLFULQJJWIF-UHFFFAOYSA-N

物化性质

• 沸点：
  354.7±27.0 °C(Predicted)
• 密度：
  0.996±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  14
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  82.3
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  三乙烯四胺 、 methyloxirane 以 水 为溶剂， 生成 7-(2-hydroxypropyl)-4,7,10,13-tetraazahexadecane-2,15-diol 、 4,7,10-tris(2-hydroxypropyl)-4,7,10,13-tetraazahexadecane-2,15-diol 、 1-[[2-[[2-[(2-氨基乙基)氨基]乙基]氨基]乙基]氨基]丙-2-醇 、 4,7,10,13-tetrakis(2-hydroxypropyl)-4,7,10,13-tetraazahexadecane-2,15-diol 、 4,7,10,13-四氮杂十六烷-2,15-二醇 、 7,10-bis(2-hydroxypropyl)-4,7,10,13-tetraazahexadecane-2,15-diol
  参考文献：
  名称：

  [EN] AMINOALCOHOL COMPOUNDS AND THEIR USE AS ZERO OR LOW VOC ADDITIVES FOR PAINTS AND COATINGS
  [FR] COMPOSÉS D'ALCOOL AMINÉ ET LEUR UTILISATION EN TANT QU'ADDITIFS À TENEUR DE COV NULLE OU BASSE POUR PEINTURES ET REVÊTEMENTS

  摘要：

  提供了氨基醇化合物，用作涂料和涂层中的添加剂。所述化合物的公式为I：其中p，m，n，R，R1，R2，R3，R4，R5和R6如本文所定义。

  公开号：

  WO2013016269A1

文献信息

• AMINOALCOHOL LIPIDOIDS AND USES THEREOF
  申请人：Mahon Kerry Peter

  公开号：US20110293703A1

  公开（公告）日：2011-12-01

  Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

  本文描述了通过将胺与环氧末端化合物反应制备氨基醇脂质体的方法。还提供了从商业起始材料制备氨基醇脂质体的方法。氨基醇脂质体可以从外消旋或立体化学纯的环氧化合物制备。氨基醇脂质体或其盐形式最好是可生物降解和生物相容的，并可用于各种药物输送系统。鉴于这些氨基醇脂质体化合物的氨基基团，它们特别适用于多核苷酸的输送。已经制备了包含创新脂质体和多核苷酸的复合物、胶束、脂质体或粒子。创新脂质体也可以用于制备药物输送的微粒。鉴于它们能够缓冲其周围环境的pH值，它们在输送不稳定剂方面特别有用。
• COMPOSITION FOR USE IN METAL WORKING
  申请人：NIPPON KOKAN KABUSHIKI KAISHA

  公开号：EP0148274A1

  公开（公告）日：1985-07-17

  A lubricating composition containing a cationic compound obtained by neutralizing a condensate between an aliphatic dicarboxylic acid and an aliphatic basic nitrogen compound with an oxygen acid of phosphorus or a derivative thereof. This composition is water-soluble, shows excellent lubricating properties, and undergoes less changes in lubricating properties and less deterioration of an oil component, thus being extremely useful.

  一种润滑组合物，含有一种阳离子化合物，该阳离子化合物是通过中和脂肪族二羧酸和脂肪族碱性氮化合物与磷的氧酸或其衍生物之间的缩合物而获得的。 这种组合物具有水溶性，显示出优异的润滑性能，并且润滑性能的变化较小，油成分的劣化程度也较低，因此非常有用。
• Aqueous ink composition
  申请人：SEIKO EPSON CORPORATION

  公开号：EP1188803A1

  公开（公告）日：2002-03-20

  An aqueous ink composition comprising at least: a surface-modified pigment capable of at least one of dispersing and dissolving in an aqueous solvent without use of a dispersant; an organic amine compound having a propanol skeleton; and water. Also disclosed are an aqueous ink composition comprising at least a pigment, a dispersant, an organic amine compound having a propanol skeleton, a penetration accelerator and water, and an aqueous ink composition comprising at least a coloring agent, water, and at least one organic amine compound selected from the group consisting of hydroxyisopropyl dimethylamine, hydroxyisopropyl diisopropylamine, hydroxyisopropyl dibutylamine, dihydroxyisopropyl ethylamine, dihydroxyisopropyl isopropylamine, dihydroxyisopropyl butylamine, dihydroxyisopropyl hydroxyethylamine, dihydroxyethyl hydroxyisopropylamine, dihydroxyethyl-n-butylamine, hydroxyethyl diisopropylamine and hydroxyethyl di-n-butylamine.

  一种水性油墨组合物，至少包含：一种表面改性颜料，能够在不使用分散剂的情况下分散和溶解于水性溶剂中的至少一种；一种具有丙醇骨架的有机胺化合物；以及水。还公开了一种水性油墨组合物，至少包含一种颜料、一种分散剂、一种具有丙醇骨架的有机胺化合物、一种渗透促进剂和水；以及一种水性油墨组合物，至少包含一种着色剂、水和至少一种选自羟基异丙基二甲基胺的有机胺化合物、羟基异丙基二异丙基胺、羟基异丙基二丁基胺、二羟基异丙基乙胺、二羟基异丙基异丙基胺、二羟基异丙基丁胺、二羟基异丙基羟乙基胺、二羟乙基羟基异丙基胺、二羟乙基正丁基胺、羟乙基二异丙基胺和羟乙基二正丁基胺。
• Aminoalcohol lipidoids and uses thereof
  申请人：Massachusetts Institute of Technology

  公开号：US10189802B2

  公开（公告）日：2019-01-29

  Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

  本文介绍了通过胺与环氧化物封端化合物反应制备氨基醇脂质的方法。还提供了从市售起始原料制备氨基醇类脂质的方法。氨基醇脂质可由外消旋或立体化学纯环氧化物制备。氨基醇类脂质或其盐类最好具有生物降解性和生物相容性，可用于各种给药系统。考虑到这些氨基醇类脂化合物的氨基，它们特别适合用于多核苷酸的给药。现已制备出含有本发明类脂化合物和多核苷酸的复合物、胶束、脂质体或颗粒。本发明的类脂质还可用于制备给药微粒。由于本发明脂质具有缓冲周围环境 pH 值的能力，因此在递送易变药剂方面特别有用。
• Polyamides and amidoamines derived from hydroxyalkylpolyamines: epoxy curing agents with improved properties
  申请人：Evonik Operations GmbH

  公开号：US11530293B2

  公开（公告）日：2022-12-20

  Polyamide and amidoamine curing agents comprising a selectively modified amine. The selectively modified amine is formed by a substitution reaction between a polyamine and an epoxide, resulting in a multifunctional amine having a hydroxyl substituent. The curing agents are used to form epoxy resins having improved properties when cured.

  由选择性改性胺组成的聚酰胺和氨基胺固化剂。选择性改性胺是通过聚胺和环氧化物之间的取代反应形成的，从而产生具有羟基取代基的多功能胺。固化剂用于形成固化后性能更佳的环氧树脂。