1-丁基-3-甲基哌嗪 | 109055-57-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 1-丁基-3-甲基哌嗪
• 英文名称: 2-metil-4-n.butilpiperazina
• 英文别名: 1-butyl-3-methyl-piperazine；1-Butyl-3-methyl-piperazin；1-Butyl-3-methylpiperazine
• CAS: 109055-57-4
• 化学式: C₉H₂₀N₂
• 分子量: 156.271
• InChiKey: PHZSRKRJHYCDKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933599090

反应信息

• 作为产物：
  描述：

  正溴丁烷 、 2-甲基哌嗪 以 苯 为溶剂， 反应 4.0h， 以11%的产率得到1,4-di-n.butil-2-metilpiperazina
  参考文献：
  名称：

  Landriani; Barlocco; Cignarella, Farmaco, Edizione Scientifica, 1987, vol. 42, # 3, p. 191 - 204

  摘要：

  DOI：

文献信息

• PROCESS FOR PRODUCTION OF POLYESTER-CONTAINING FLEXIBLE POLYURETHANE FOAM, AND CATALYST COMPOSITION FOR USE IN THE PROCESS
  申请人：Tosoh Corporation

  公开号：EP2204394A1

  公开（公告）日：2010-07-07

  To provide a method for producing a low-odor polyester-type flexible polyurethane foam which is excellent in formability and free from scorch in the interior of the foam, and further discharges substantially no volatile amine compound from a product, in the production of a polyester-type flexible polyurethane foam, and to provide a catalyst composition to be used for the production method. A polyester-type flexible polyurethane foam is produced by a process which comprises reacting a polyester polyol with a polyisocyanate, in the presence of a catalyst composition containing one or more amine compounds selected from the group consisting of an amine compound represented by the following formula (1): in the above formula (1), R1 is a C1-6 linear or branched alkyl group, and each of R2, R3, R4 and R5 which are independent of one another, is a hydrogen atom or a C1-2 alkyl group, an amine compound represented by the following formula (2): in the above formula (2), R6 is a C2-6 linear or branched alkylene group, and an amine compound represented by the following formula (3): in the above formula (3), each of R7 and R8 which are independent of each other, is a C1-4 alkyl group, and R9 is a C3-5 linear or branched alkylene group; a blowing agent; and a surfactant.

  提供一种生产低气味聚酯型软质聚氨酯泡沫塑料的方法，该泡沫塑料具有良好的成型性，泡沫塑料内部无焦烧现象，而且在生产聚酯型软质聚氨酯泡沫塑料时，产品中基本上不排放挥发性胺化合物，并提供一种用于该生产方法的催化剂组合物。 聚酯型软质聚氨酯泡沫塑料的生产工艺包括：在催化剂组合物存在的情况下，使聚酯多元醇与多异氰酸酯反应，催化剂组合物含有一种或多种胺化合物，这些胺化合物选自由下式(1)所代表的胺化合物组成的组： 在上式（1）中，R1 是 C1-6 直链或支链烷基，R2、R3、R4 和 R5 中的每一个彼此独立，是氢原子或 C1-2 烷基、 下式(2)所代表的胺化合物： 在上式（2）中，R6 是 C2-6 直链或支链亚烷基，以及下式（3）代表的胺化合物： 在上式（3）中，相互独立的 R7 和 R8 均为 C1-4 烷基，R9 为 C3-5 直链或支链亚烷基；发泡剂；以及表面活性剂。
• Indazolones as modulators of tnf signaling
  申请人：AbbVie Inc.

  公开号：US10160748B2

  公开（公告）日：2018-12-25

  The disclosure provides indazolone compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the disclosure may be useful for treating immunological and oncological conditions.

  本公开提供了吲唑酮化合物、药学上可接受的盐、原药、生物活性代谢物、立体异构体和异构体，其中变量在本文中定义。本公开的化合物可用于治疗免疫学和肿瘤学疾病。
• METHOD FOR PRODUCING POLYESTER TYPE FLEXIBLE POLYURETHANE FOAM, AND CATALYST COMPOSITION TO BE USED THEREFOR
  申请人：Takahashi Yoshihiro

  公开号：US20100256249A1

  公开（公告）日：2010-10-07

  To provide a method for producing a low-odor polyester-type flexible polyurethane foam which is excellent in formability and free from scorch in the interior of the foam, and further discharges substantially no volatile amine compound from a product, in the production of a polyester-type flexible polyurethane foam, and to provide a catalyst composition to be used for the production method. A polyester-type flexible polyurethane foam is produced by a process which comprises reacting a polyester polyol with a polyisocyanate, in the presence of a catalyst composition containing one or more amine compounds selected from the group consisting of an amine compound represented by the following formula (1): in the above formula (1), R 1 is a C 1-6 linear or branched alkyl group, and each of R 2 , R 3 , R 4 and R 5 which are independent of one another, is a hydrogen atom or a C 1-2 alkyl group, an amine compound represented by the following formula (2): in the above formula (2), R 6 is a C 2-6 linear or branched alkylene group, and an amine compound represented by the following formula (3): in the above formula (3), each of R 7 and R 8 which are independent of each other, is a C 1-4 alkyl group, and R 9 is a C 3-5 linear or branched alkylene group; a blowing agent; and a surfactant.
• INDAZOLONES AS MODULATORS OF TNF SIGNALING
  申请人：AbbVie Inc.

  公开号：US20180086737A1

  公开（公告）日：2018-03-29

  The disclosure provides indazolone compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the disclosure may be useful for treating immunological and oncological conditions.
• METHODS FOR TREATING OR PREVENTING CARDIOVASCULAR DISORDERS AND LOWERING RISK OF CARDIOVASCULAR EVENTS
  申请人：DALCOR PHARMA UK LTD., LEATHERHEAD, ZUG BRANCH

  公开号：US20210290623A1

  公开（公告）日：2021-09-23

  The invention provides compositions and methods useful for treating or preventing cardiovascular disorders and lowering risk of cardiovascular events.