1-丁基-4-甲基萘 | 52718-76-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 1-丁基-4-甲基萘
• 英文名称: 1-butyl-4-methylnaphthalene
• 英文别名: 1-methyl-4-butylnaphthalene；1-n-butyl-4-methylnaphthalene；1-n-Butyl-4-methylnaphthalin
• CAS: 52718-76-0
• 化学式: C₁₅H₁₈
• 分子量: 198.308
• InChiKey: ZWRABTBXVLAGFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2902909090

反应信息

• 作为产物：
  描述：

  1-丁基-4-甲基-1,4-二氢萘-1,4-二醇 在 氢碘酸 作用下， 以 四氢呋喃 为溶剂， 生成 1-丁基-4-甲基萘
  参考文献：
  名称：

  竞争性二烯酮-苯酚类型重排用于2,4-二取代-萘-1-醇的区域选择性制备

  摘要：

  描述了通过二烯酮-苯酚重排的变体的2,4-取代的萘-1-醇的区域选择性制备。

  DOI：

  10.1016/s0040-4039(00)80619-x

文献信息

• A New Titanium Tetrachloride Mediated Annulation of α-Aryl-Substituted Carbonyl Compounds with Alkynes:  A Simple and Highly Efficient Method for the Regioselective Synthesis of Polysubstituted Naphthalene Derivatives
  作者：George W. Kabalka、Yuhong Ju、Zhongzhi Wu

  DOI：10.1021/jo034330o

  日期：2003.10.1

  A new straightforward procedure has been developed for the synthesis of polysubstituted naphthalene derivatives. The reaction of alpha-aryl-substituted carbonyl compounds with terminal or internal alkynes in the presence of TiCl4 regioselectively generates substituted naphthalene derivatives in good to excellent yields.

  已经开发了用于合成多取代的萘​​衍生物的新的直接方法。在TiCl4的存在下，α-芳基取代的羰基化合物与末端或内部炔烃的反应可以区域选择性地生成取代的萘衍生物，收率好至极好。
• Metal-free synthesis of indanes by iodine(III)-mediated ring contraction of 1, 2-dihydronaphthalenes
  作者：Fernanda A Siqueira、Eloisa E Ishikawa、André Fogaça、Andréa T Faccio、Vânia M. T Carneiro、Rafael R. S Soares、Aline Utaka、Iris R. M Tébéka、Marcin Bielawski、Berit Olofsson、Luiz F Silva Jr

  DOI：10.1590/s0103-50532011000900024

  日期：——

  A metal-free protocol was developed to synthesize indanes by ring contraction of 1,2-dihydronaphthalenes promoted by PhI(OH) OTs (HTIB or Koser's reagent). This oxidative rearrangement can be performed in several solvents (MeOH, CH3CN, 2,2,2-trifluoroethanol (TFE), 1,1,1,3,3,3-hexafluoroisopropanol (HFIP), and a 1: 4 mixture of TFE: CH2Cl2) under mild conditions. The ring contraction diastereoselectively gives functionalized trans-1,3-disubstituted indanes, which are difficult to obtain in synthetic organic chemistry.
• Tetrahydrofuran-promoted aryl-alkyl coupling involving organolithium reagents
  作者：Ronald E. Merrill、Eiichi Negishi

  DOI：10.1021/jo00937a048

  日期：1974.11
• Thallium trinitrate-mediated ring contraction of 1,2-dihydronaphthalenes: an approach to the synthesis of indans
  作者：Helena M.C Ferraz、Luiz F Silva、Tiago O Vieira

  DOI：10.1016/s0040-4020(00)01174-1

  日期：2001.2

  Oxidation of 1,2-dihydronaphthalenes with thallium trinitrate was studied. 1,2-dihydronaphthalene, 1-methyl-1,2-dihydronaphthalene, 6- and 8-methoxy-1,2-dihydronaphthalenes gave rise to the respective ring contraction products in good yields, whereas the rearrangement was not observed using 4-methyl-1,2-dihydronaphthalene and 1-n-butyl-4-methyl-1,2-dihydronaphthalene as substrates. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Bil'kis, I.I.; Vaganova, T.A.; Shteingarts, V.D., Russian Journal of Organic Chemistry, 1994, vol. 30, # 6.2, p. 951 - 956
  作者：Bil'kis, I.I.、Vaganova, T.A.、Shteingarts, V.D.

  DOI：——

  日期：——