1-乙酰氨基-4-氰基-3-甲基异喹啉 | 179985-52-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 中文名称: 1-乙酰氨基-4-氰基-3-甲基异喹啉
• 英文名称: 1-Acetamido-4-cyano-3-methylisoquinoline
• 英文别名: N-(4-cyano-3-methylisoquinolin-1-yl)acetamide
• CAS: 179985-52-5
• 化学式: C₁₃H₁₁N₃O
• mdl: MFCD04039368
• 分子量: 225.25
• InChiKey: SRNACQXBALMDDC-UHFFFAOYSA-N

物化性质

• 熔点：
  200-202°C
• 沸点：
  489.7±45.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.153
• 拓扑面积：
  65.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• METHOD OF USING PROTEIN KINASE A ACTIVATOR AND INHIBITOR IN PREPARATION OF DRUGS FOR TREATING DISEASES ASSOCIATED WITH CHANGES IN PLATELET COUNTS AND FOR INHIBITING AND PROMOTING PLATELET APOPTOSIS
  申请人：Soochow university

  公开号：US20190343861A1

  公开（公告）日：2019-11-14

  A method of using protein kinase A (PKA) activator and inhibitor in preparations of drugs for treating diseases associated with changes in platelet counts. Protein kinase A regulates platelet apoptosis by means of regulating the phosphorylation of serine at BAD position 155; the activation of protein kinase A activity may inhibit the occurrence of endogenous platelet apoptosis, and may also increase circulating platelet counts in experimental animals; in addition, inhibiting PKA activity may induce platelet apoptosis in vitro, while also reducing circulating platelet counts in the body, indicating that PKA inhibitors may participate in the treatment of thrombocytosis, and reduce platelet counts in peripheral circulating blood.