1-氮鎓杂二环[2.2.2]辛烷,1-甲基- | 15302-92-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 中文名称: 1-氮鎓杂二环[2.2.2]辛烷,1-甲基-
• 英文名称: N-methyl quinuclidinium
• 英文别名: N-Methyl-chinuclidinium；1-Methyl-1-azoniabicyclo[2.2.2]octane
• CAS: 15302-92-8
• 化学式: C₈H₁₆N
• 分子量: 126.222
• InChiKey: MFQQHFRKVCFEBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• Oxypentafluorosulfate compositions and processes for making them
  申请人：Syvret Robert George

  公开号：US20080033164A1

  公开（公告）日：2008-02-07

  Novel compositions are provided containing a compound represented by the formula YOSF 5 or ZOSF 5 , where: (a) Y is: (i) an organic cation other than (Me 2 N) 3 S + or (ii) an inorganic cation, provided that when Y is the inorganic cation, the composition further includes a complexing agent; and (b) Z is C 1-20 alkyl, aryl, cycloalkyl, combinations thereof, or analogues thereof containing at least one heteroatom, provided that the compound represented by the formula ZOSF 5 is a molecular compound. Processes of making the cationic compounds are disclosed as are processes for using the compositions containing cationic compounds in nucleophilic replacement reactions to prepare the compositions containing molecular compounds including the OSF 5 group.

  提供含有由公式YOSF5或ZOSF5表示的化合物的小说组合物，其中：(a) Y是：(i) 除(Me2N)3S+之外的有机阳离子，或者(ii) 无机阳离子，但是当Y是无机阳离子时，组合物还包括络合剂；和(b) Z是C1-20烷基，芳香族，环烷基，它们的组合物，或者至少含有一个杂原子的类似物，但是由公式ZOSF5表示的化合物是一个分子化合物。公开了制备阳离子化合物的方法，以及使用含有阳离子化合物的组合物进行亲核取代反应以准备含有OSF5基团的分子化合物的方法。
• Muscarinic receptor antagonists
  申请人：——

  公开号：US20040110229A1

  公开（公告）日：2004-06-10

  Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an allosteric modulator provided that at least one of said ligand is a muscarinic receptor antagonist. The multibinding compounds of this invention are useful in the treatment and prevention of diseases such as chronic obstructive pulmonary disease, chronic bronchitis, irritable bowel syndrome, urinary incontinence, and the like.

  本发明揭示了多结合配合物，其为胆碱能受体拮抗剂。本发明的多结合配合物包含2至10个配体共价连接到一个或多个连接剂上。每个配体独立于其他配体，是胆碱能受体拮抗剂或别构调节剂，但至少其中一个配体是胆碱能受体拮抗剂。本发明的多结合配合物在治疗和预防慢性阻塞性肺疾病、慢性支气管炎、肠易激综合征、尿失禁等疾病中有用。
• Quaternary salt derivatives of 1,4-diphenylazetidin-2-ones
  申请人：Martinez J. Eduardo

  公开号：US20070072812A1

  公开（公告）日：2007-03-29

  Quaternary salt derivatives of 1,4-diphenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formulae as well as isomers of these formulae.

  本文揭示了1,4-二苯基氮杂四环酮的季铵盐衍生物，可用于治疗高胆固醇血症。这些化合物的一般式如下，并包括这些式的异构体。
• Novel uses of porphyrin compounds
  申请人：Love G. William

  公开号：US20070167619A1

  公开（公告）日：2007-07-19

  The invention provides the use of a compound of Formula (I), or metallated derivative thereof, in the preparation of a medicament for killing or attenuating the growth of microorganisms by a method which does not comprise exposing the compound to a photodynamic therapy light source or a sonodynamic therapy ultrasound source Formula (I) wherein X 1 , X 2 , X 3 , X 4 , Yi, Y 2 , Y 3 , Y 4 and Z have meanings given in the description. Preferably, the microorganisms are selected from the group consisting off bacteria, mycoplasmas, yeasts, fungi and viruses.

  本发明提供了使用式(I)的化合物或其金属衍生物，在制备杀灭或减弱微生物生长的药物时使用，其方法不包括将该化合物暴露于光动力疗法光源或声动力疗法超声源中。(I)式中，X1、X2、X3、X4、Yi、Y2、Y3、Y4和Z的含义在说明书中给出。优选的微生物来自细菌、支原体、酵母菌、真菌和病毒等群体。
• Novel benzothiazepine and bensothiepine compounds
  申请人：Sasahara Takehiko

  公开号：US20070190041A1

  公开（公告）日：2007-08-16

  A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis and primary sclerosing cholangitis, and a pharmaceutical useful as a therapeutic agent and a preventive agent for obesity, fatty liver and steatohepatitis are provided. A benzothiazepine or benzothiepine compound represented by the following formula (1A) having a thioamide bond and a quaternary ammonium substitutent:

  提供了一种药物，可用作治疗和预防高脂血症的治疗剂和预防剂，以及一种药物，可用作治疗和预防与胆汁淤积有关的肝脏疾病，特别是原发性胆汁性肝硬化和原发性硬化性胆管炎的治疗剂和预防剂，以及一种药物，可用作治疗和预防肥胖症、脂肪肝和脂肪性肝炎的治疗剂和预防剂。化合物的苯并噻吩或苯并噻环代表如下式（1A），具有硫酰胺键和季铵取代基：