1-溴-1-氯戊烷 | 74732-64-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 中文名称: 1-溴-1-氯戊烷
• 英文名称: chloro-1 bromo-1 pentane
• 英文别名: 1-Bromo-1-chloropentane；bromo-1 chloro-1 pentane；1-bromopentyl chloride；1-bromo-α-chloro-pentane；bromochloropentane
• CAS: 74732-64-2
• 化学式: C₅H₁₀BrCl
• 分子量: 185.491
• InChiKey: NXFBJNIZJZYWAC-UHFFFAOYSA-N

物化性质

• 沸点：
  88 °C(Press: 70 Torr)
• 密度：
  1.363±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  丙酸甲酯 、 1-溴-1-氯戊烷 生成 4-氯辛烷-3-酮
  参考文献：
  名称：

  Regiospecific Synthesis of α-Haloketones using α-Haloalkyllithium Reagents

  摘要：

  DOI：

  10.1055/s-1981-29343
• 作为产物：
  描述：

  1-碘丁烷 、 溴氯甲烷 生成 1-溴-1-氯戊烷
  参考文献：
  名称：

  Regiospecific Synthesis of α-Haloketones using α-Haloalkyllithium Reagents

  摘要：

  DOI：

  10.1055/s-1981-29343

文献信息

• [EN] NOVEL N-SUBSTITUTED DIHYDROBENZOTHIEPINO, DIHYDROBENZOXEPINO AND TETRAHYDRO BENZOCYCLOHEPTA INDOLES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS<br/>[FR] NOUVEAUX DIHYDROBENZOTHIEPINO, DIHYDROBENZOXEPINO ET TETRAHYDRO BENZOCYCLOHEPTA INDOLES N-SUBSTITUES UTILISES EN TANT QUE MODULATEURS DU RECEPTEUR DES OESTROGENES
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2005094833A1

  公开（公告）日：2005-10-13

  The invention provides a novel class of N-substituted dihydrobenzothiepino, dihydrobenzoxepino and tetrahydro benzocyclohepta indoles of Formula (I) and their pharmaceutically acceptable salts, and methods for of synthesizing these compounds. The invention further comprises pharmaceutical compositions and methods of use for these compounds for the treatment of estrogen related diseases or disorders.

  这项发明提供了一类新型的Formula (I)的N-取代二氢苯并噻吩、二氢苯并氧吩和四氢苯并环庚哌啉以及它们的药用盐，以及合成这些化合物的方法。该发明还包括用于治疗雌激素相关疾病或紊乱的这些化合物的药用组合物和使用方法。
• [EN] NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS<br/>[FR] NOUVELLES AMIDINES DE THIOPHENE, COMPOSITIONS DE CES AMIDINES ET PROCEDE POUR TRAITER DES MALADIES ET DES ETATS MEDIES PAR LE COMPLEMENT
  申请人：DIMENSIONAL PHARM INC

  公开号：WO2003099805A1

  公开（公告）日：2003-12-04

  Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.

  揭示了一种治疗急性或慢性疾病症状的方法，该方法通过补体级联的经典途径介导，包括向需要此类治疗的哺乳动物施用化合物I的治疗有效量或其溶剂化合物、水合物或药用可接受盐；其中规范中定义了R1、R2、R3、R4和R7，Z为SO或SO2，Ar为本规范中定义的芳香族或杂环芳基。
• [EN] NOVEL BENZAMIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OSTEOPOROSIS COMPRISING THE SAME<br/>[FR] NOUVEAUX DÉRIVÉS DE BENZAMIDINE, PROCÉDÉ DE PRÉPARATION CORRESPONDANT ET COMPOSITION PHARMACEUTIQUE LES CONTENANT QUI PERMET DE PRÉVENIR OU DE TRAITER L'OSTÉOPOROSE
  申请人：DONG WHA PHARM IND CO LTD

  公开号：WO2009017346A1

  公开（公告）日：2009-02-05

  The present invention relates to novel benzamidine derivatives, a process for the preparation thereof and a pharmaceutical composition for preventing or treating osteoporosis comprising the same. The benzamidine derivatives of the present invention effectively inhibit osteoclast differentiation at an extremely low concentration, and thus can be advantageously used for the prevention and treatment of osteoporosis.

  本发明涉及新型苯甲酰胺衍生物，其制备方法以及包含其的用于预防或治疗骨质疏松症的药物组合物。本发明的苯甲酰胺衍生物在极低浓度下有效抑制成骨细胞的分化，因此可有利地用于预防和治疗骨质疏松症。
• [EN] AN IMPROVED PROCESS FOR PREPARING N-HYDROXY-4-{5- [4- (5-ISOPROPYL-2-METHYL-l, 3-THIAZOL-4-YL) -PHENOXY] -PENTOXY }-BENZAMIDINE<br/>[FR] METHODE AMELIOREE SERVANT A PREPARER N-HYDROXY-4{5-[4-(5-ISOPROPYL-2-METHYL-1,3-THIAZOL-4-YL)-PHENOXY]-PENTOXY}-BENZAMIDINE
  申请人：DONG WHA PHARM IND CO LTD

  公开号：WO2006004368A1

  公开（公告）日：2006-01-12

  This invention relates to an improved method of preparing N-hydroxy-4-5- [4- (5-isopropyl-2-methyl-l, 3-thiazol-4-yl) phenoxy] pentoxy }benzamidine .

  这项发明涉及一种改进的制备N-羟基-4-5-[4-(5-异丙基-2-甲基-1,3-噻唑-4-基)苯氧基]戊氧基}苯甲酰胺的方法。
• [EN] NOVEL PROCESS FOR THE PREPARATION OF CILASTATIN SODIUM SALT<br/>[FR] NOUVEAU PROCEDE DE PREPARATION D'UN SEL DE SODIUM DE CILASTATINE
  申请人：DONG KOOK PHARM CO LTD

  公开号：WO2006022511A1

  公开（公告）日：2006-03-02

  The present invention relates to a novel process for preparing cilastatin sodium salt used asa dehydropeptidase 1 inhibitor. The novel method of the present invention could prevent the formation of (E)-isomer from the preparation of intermediate for preparing cilastatin sodium, i.e., (Z)-7-chloro-2-((S)-2,2-dimethylcyclopropanecarboxarnido)-2-heptenoic acid metal salt and isolate the intermediate in situ providing simpler process with high yield and purity. Furthermore, it can provide with highly pure cilastatin sodium salt by isolating novel cilastatin amine salt and using by sodium hydroxide and cationic exchange resin. Accordingly, the method can be very useful in preparing cilastatin sodium salt with high yield and high purity.

  本发明涉及一种用作脱氢肽酶1抑制剂的盐酸西拉斯汀的新型制备工艺。本发明的新方法可以防止从制备盐酸西拉斯汀的中间体（Z）-7-氯-2-((S)-2,2-二甲基环丙基羧氨基)-2-庚烯酸金属盐形成（E）-异构体，并在原位分离中间体，提供了高产率和纯度的简化过程。此外，通过分离新型西拉斯汀胺盐并使用氢氧化钠和阳离子交换树脂，可以提供高纯度的盐酸西拉斯汀盐。因此，该方法在制备高产率和高纯度的盐酸西拉斯汀盐方面非常有用。