1-环己基-4-[3-(1,2,3,4-四氢-5-甲氧基-1-萘基)丙基]哌嗪二盐酸盐 | 172907-03-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 中文名称: 1-环己基-4-[3-(1,2,3,4-四氢-5-甲氧基-1-萘基)丙基]哌嗪二盐酸盐
• 英文名称: PB28 dihydrochloride
• 英文别名: 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine;dihydrochloride
• CAS: 172907-03-8
• 化学式: C24H40Cl2N2O
• 分子量: 443.5
• InChiKey: DSRBJOQIBXACIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.69
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  15.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• METHODS OF IDENTIFYING AND TREATING TUMORS WITH SIGMA1 INHIBITORS
  申请人：DREXEL UNIVERSITY

  公开号：US20200087730A1

  公开（公告）日：2020-03-19

  Methods and uses of using Sigma1 inhibitors are provide herein, including diagnostic methods for predicting or identifying quantitatively whether a human tumor is responsive or non-responsive to treatment with Sigma1 inhibition are also provided.
• [EN] METHODS OF IDENTIFYING AND TREATING TUMORS WITH SIGMA1 INHIBITORS<br/>[FR] MÉTHODES D'IDENTIFICATION ET DE TRAITEMENT DE TUMEURS AVEC DES INHIBITEURS DE SIGMA1
  申请人：UNIV DREXEL

  公开号：WO2018112122A1

  公开（公告）日：2018-06-21

  Methods and uses of using Sigma1 inhibitors are provide herein, including diagnostic methods for predicting or identifying quantitatively whether a human tumor is responsive or non-responsive to treatment with Sigma1 inhibition are also provided.