1-甲基-3,3-二(2-羟基乙基)脲 | 37437-17-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 中文名称: 1-甲基-3,3-二(2-羟基乙基)脲
• 英文名称: N,N-bis(2-hydroxyethyl)-N'-methyl-urea
• 英文别名: N-Methyl-N',N'-bis-<2-hydroxy-ethyl>-harnstoff；N,N-Bis(2-hydroxyethyl)-N'-methylurea；1,1-bis(2-hydroxyethyl)-3-methylurea
• CAS: 37437-17-5
• 化学式: C₆H₁₄N₂O₃
• 分子量: 162.189
• InChiKey: VEEUFWDGCHUMFT-UHFFFAOYSA-N

物化性质

• 密度：
  1.194

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  72.8
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二乙醇胺 、 异氰酸甲酯 以 氯仿 为溶剂， 生成 1-甲基-3,3-二(2-羟基乙基)脲
  参考文献：
  名称：

  抗肿瘤剂的合成。XXXII。N-硝基 一世。

  摘要：

  DOI：

  10.1021/jm00342a010

文献信息

• Nonaqueous ascorbic acid compositions and methods for preparing same
  申请人：Zhang Jerry

  公开号：US20070172436A1

  公开（公告）日：2007-07-26

  A method for preparing a nonaqueous ascorbic acid composition in an alcohol solvent comprising ascorbic acid, a solubilization enhancer, and an oleaginous skin protectant is described. The amount of ascorbic acid dissolved in the nonaqueous composition in the presence of the solubilization enhancer is greater than the amount of ascorbic acid that would be soluble in the solvent in the absence of the solubilization enhancer. A nonaqueous composition comprises the dissolved ascorbic acid, solubilization enhancer, and homogenized oleaginous skin protectant.
• Non-aqueous compositions containing urea and allantoin and methods for preparing same
  申请人：Zhang Jerry

  公开号：US20080057002A1

  公开（公告）日：2008-03-06

  A method for enhancing solubility of allantoin in a non-aqueous pharmaceutically acceptable alcohol carrier using a solubilization enhancer is described. Non-aqueous compositions containing the solubilized allantoin at the FDA-approved levels of 0.5% to 2% by weight are able to be obtained by using urea or urea derivatives as the solubilization enhancer. The non-aqueous topical composition is suitable for cosmetic, dermatological, and pharmaceutical use.
• Topical compositions containing solubilized allantoin and related methods
  申请人：Zhang Jerry

  公开号：US20080081052A1

  公开（公告）日：2008-04-03

  A method for enhancing solubility of allantoin in an aqueous vehicle using a solubilization enhancer is described. Aqueous compositions containing the solubilized allantoin at a level of 0.5% by weight or higher are able to be obtained by using urea or urea derivatives as the solubilization enhancer. The aqueous topical compositions are suitable for cosmetic, dermatological, and pharmaceutical use.
• The Synthesis of Antineoplastic Agents. XXXII. N-Nitrosoureas.¹ I.
  作者：Thomas P. Johnston、George S. McCaleb、John A. Montgomery

  DOI：10.1021/jm00342a010

  日期：1963.11

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