1-碘-7-甲基萘 | 70109-76-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 1-碘-7-甲基萘
• 英文名称: 1-iodo-7-methylnaphthalene
• 英文别名: 2-Methyl-8-jodnaphtalin
• CAS: 70109-76-1
• 化学式: C₁₁H₉I
• 分子量: 268.097
• InChiKey: RYYURXRXGCCPOP-UHFFFAOYSA-N

物化性质

• 沸点：
  324.8±11.0 °C(Predicted)
• 密度：
  1.655±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  1,2-二乙炔基-4-甲基苯 在 氢碘酸 、 platinum(II) chloride 作用下， 以 水 为溶剂， 反应 2.0h， 生成 1-iodo-6-methylnaphthalene 、 1-碘-7-甲基萘
  参考文献：
  名称：

  Regioselective Haloaromatization of 1,2-Bis(ethynyl)benzene via Halogen Acids and PtCl₂. Platinum-Catalyzed 6-π Electrocyclization of 1,2-Bis(1‘-haloethenyl)benzene Intermediates

  摘要：

  Treatment of 1,2-bis(ethynyl)benzene (1) with aqueous HX (X = Br, I) in hot 3-pentanone (100105 degrees C, 2 h) afforded 1,2-bis(1'-baloethenyl)benzene species 2-Br and 2-I in 98% and 95% yields, respectively. The hydrochlorination of endiyne 1 failed to proceed at elevated temperature but was implemented efficiently by PtCl2 (5 mol %) in hot 3-pentanone (100 degrees C, 2 h) to give 1,2-bis(1'-chloroethenyl)benzene 2-Cl in 80% yield. In the presence of PtCl2 (5 mol %), these halides 2-Cl, 2-Br, and 2-I were subsequently converted to 1-halonaphthalenes 3-Cl, 3-Br, and 3-I in the mother solution via sequential 6-pi electrocyclization and dehalogenation reactions. PtCl2 (5 mol %) also effected direct haloaromatization of endiyne 1 with HX (X = Cl, Br, 1) and gave 1-halonaphthalenes 3-Cl, 3-Br, and 3-I in 64-71% yields. This investigation reports the scope and the regioselectivity of haloaromatization of various enediynes catalyzed by PtCl2.

  DOI：

  10.1021/jo0518295

文献信息

• [EN] ANTI-EGFR ANTIBODY DRUG CONJUGATES<br/>[FR] CONJUGUÉS MÉDICAMENT-ANTICORPS ANTI-EGFR
  申请人：ABBVIE INC

  公开号：WO2017214301A1

  公开（公告）日：2017-12-14

  The invention relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods of using said ADCs.

  本发明涉及抑制Bcl-xL的抗表皮生长因子受体（EGFR）抗体药物偶联物（ADCs），包括所述ADCs的组成物和使用方法。
• CONDENSED CYCLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME, AND DISPLAY APPARATUS INCLUDING THE ORGANIC LIGHT-EMITTING DEVICE
  申请人：SAMSUNG DISPLAY CO., LTD.

  公开号：US20200190113A1

  公开（公告）日：2020-06-18

  A condensed cyclic compound is represented by Formula 1. An organic light-emitting device includes: a first electrode; a second electrode; and an organic layer between the first electrode and the second electrode and comprising an emission layer, the organic layer including the condensed cyclic compound represented by Formula 1. A display apparatus includes: a thin-film transistor comprising a source electrode, a drain electrode, and an active layer; and the organic light-emitting device.

  一种紧缩环化合物由化学式1表示。一种有机发光器件包括：第一电极；第二电极；以及位于第一电极和第二电极之间的有机层，包括一个发射层，该有机层包括由化学式1表示的紧缩环化合物。一种显示装置包括：包括源电极、漏极和有源层的薄膜晶体管；以及该有机发光器件。
• CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
  申请人：SAMSUNG DISPLAY CO., LTD.

  公开号：US20200052223A1

  公开（公告）日：2020-02-13

  A condensed cyclic compound and an organic light-emitting device including the same, the condensed cyclic compound being represented by the following Formula 1:

  一种缩合环化合物及包括该化合物的有机发光器件，所述缩合环化合物由下式1表示：
• CONDENSED CYCLIC COMPOUND, COMPOSITION INCLUDING THE SAME, AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THIN FILM FORMED FROM THE COMPOSITION
  申请人：Samsung Display Co., Ltd.

  公开号：US20200181045A1

  公开（公告）日：2020-06-11

  Provided are a condensed cyclic compound, a composition including the same, and an organic light-emitting device including a thin film formed from the composition. The condensed cyclic compound is represented by following Formula, has a molecular weight of about 400 to about 10,000, and comprises at least one cross-linkable group:

  提供了一种紧凑的环状化合物，包括该化合物的组合物以及包含从该组合物形成的薄膜的有机发光器件。该紧凑的环状化合物由以下公式表示，分子量约为400至10,000，并包含至少一个可交联基团：
• DIAMINE COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
  申请人：Samsung Display Co., Ltd.

  公开号：US20190334096A1

  公开（公告）日：2019-10-31

  A diamine compound includes a naphthyl-phenyl linker and a 2-carbazolyl group. An organic light-emitting device includes: a first electrode; a second electrode; and an organic layer between the first electrode and the second electrode and including an emission layer, wherein the organic layer includes the diamine compound including the naphthyl-phenyl linker and the 2-carbazolyl group.

  一种二胺化合物包括一个萘基苯连接器和一个2-咔唑基团。一种有机发光器件包括：第一电极；第二电极；以及位于第一电极和第二电极之间并包括发射层的有机层，其中有机层包括包括萘基苯连接器和2-咔唑基团的二胺化合物。