17-羰基雌-1,3,5(10),7-四烯-3-基硫酸酯 | 27540-07-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 17-羰基雌-1,3,5(10),7-四烯-3-基硫酸酯
• 中文别名: 马烯雌酮硫酸盐
• 英文名称: Equilin sulfate
• 英文别名: [(9S,13S,14S)-13-methyl-17-oxo-9,11,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate
• CAS: 27540-07-4
• 化学式: C₁₈H₂₀O₅S
• 分子量: 348.4
• InChiKey: YJBYRYVLFAUXBJ-HFTRVMKXSA-N

物化性质

• 密度：
  1.42±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  89
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• 6,7-Dihydro-5H-benzo[7]annulene derivatives, processes for their preparation, pharmaceutical products comprising them and their use for preparing medicaments
  申请人：Bayer Intellectual Property GmbH

  公开号：US20150080438A1

  公开（公告）日：2015-03-19

  The invention relates to selective oestrogen receptor modulators (SERMs) and to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of bleeding disorders, osteoporosis, endometriosis, myomata, hormone-dependent tumours, for hormone replacement therapy and for contraception.

  该发明涉及选择性雌激素受体调节剂（SERMs），以及它们的制备方法，它们用于治疗和/或预防疾病的用途，以及它们用于制备用于治疗和/或预防疾病的药物，特别是用于治疗出血障碍、骨质疏松症、子宫内膜异位症、子宫肌瘤、激素依赖性肿瘤、激素替代疗法和避孕的用途。
• 6,7-DIHYDRO-5H-BENZO[7]ANNULENE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, PHARMACEUTICAL PREPARATIONS COMPRISING THEM, AND THE USE THEREOF FOR PRODUCTION OF MEDICAMENTS
  申请人：Wintermantel Tim

  公开号：US20130252890A1

  公开（公告）日：2013-09-26

  The invention relates to selective oestrogen receptor modulators (SERM) and methods of production thereof, use thereof for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular of bleeding disorders, osteoporosis, endometriosis, myomata, hormone-dependent tumours, for hormone replacement therapy and for contraception.

  该发明涉及选择性雌激素受体调节剂（SERM）及其生产方法，以及将其用于治疗和/或预防疾病以及将其用于生产用于治疗和/或预防疾病的药物产品，特别是用于出血性疾病、骨质疏松症、子宫内膜异位症、子宫肌瘤、激素依赖性肿瘤、激素替代疗法和避孕。
• Cyclodextrin-drospirenone inclusion complexes
  申请人：Schering Aktiengesellschaft

  公开号：US20020173487A1

  公开（公告）日：2002-11-21

  Pharmaceutical compositions comprising low doses of sensitive complexes between an estrogen and a cyclodextrin are provided with improved stability. In specific embodiments the composition comprises a complex between ethinyl estradiol and &bgr;-cyclodextrin in a granulate preparation and in yet another embodiment the composition comprises a limited amount of polyvinylpyrrolidone since this excipient was found to degrade ethinyl estradiol. Furthermore, a method for improving the stability of an estrogen in a composition and for manufacturing such a stable composition is provided. Essentially, the granulate preparation are manufactured under careful control of the relative humidity.

  本发明提供了含有雌激素和环糊精之间低剂量敏感复合物的制药组合物，其稳定性得到了改善。在特定实施例中，该组合物包括乙炔雌酚和β-环糊精之间的复合物，以颗粒制备的形式呈现。在另一个实施例中，该组合物包括有限量的聚乙烯吡咯烷酮，因为发现这种赋形剂会降解乙炔雌酚。此外，本发明提供了一种改善组合物中雌激素稳定性并制造这种稳定组合物的方法。基本上，颗粒制备是在相对湿度的谨慎控制下制造的。
• Compositions of estrogen-cyclodextrin complexes
  申请人：Backensfeld Thomas

  公开号：US20050182024A1

  公开（公告）日：2005-08-18

  Pharmaceutical compositions comprising low doses of sensitive complexes between an estrogen and a cyclodextrin are provided with improved stability. In specific embodiments the composition comprises a complex between ethinyl estradiol and β-cyclodextrin in a granulate preparation and in yet another embodiment the composition comprises a limited amount of polyvinylpyrrolidone since this excipient was found to degrade ethinyl estradiol. Furthermore, a method for improving the stability of an estrogen in a composition and for manufacturing such a stable composition is provided. Essentially, the granulate preparation are manufactured under careful control of the relative humidity.

  提供了含有雌激素和环糊精之间低剂量敏感复合物的制药组合物，具有改善的稳定性。在特定实施例中，该组合物包括乙炔雌醇和β-环糊精的复合物，以颗粒制剂形式提供。在另一个实施例中，该组合物包括有限量的聚乙烯吡咯烷酮，因为发现该辅料会降解乙炔雌醇。此外，还提供了一种改善组合物中雌激素稳定性并制造这种稳定组合物的方法。基本上，颗粒制剂是在相对湿度的谨慎控制下制造的。
• Methods for inhibiting bone loss
  申请人：ELI LILLY AND COMPANY

  公开号：EP0744176A2

  公开（公告）日：1996-11-27

  The present invention provides methods of inhibiting bone loss in humans comprising administering to a patient in need of treatment an effective amount of d-equilenin, 17b-dihydroequilenin, and 17a-dihydroequilenin, and pharmaceutical formulations thereof.

  本发明提供了抑制人体骨质流失的方法，包括向需要治疗的患者施用有效量的d-喹啉、17b-二氢喹啉和17a-二氢喹啉及其药物制剂。