1H-吡咯并[3,2-c]吡啶-4,6(5H,7H)-二酮 | 65523-03-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 中文名称: 1H-吡咯并[3,2-c]吡啶-4,6(5H,7H)-二酮
• 英文名称: 1H-Pyrrolo<3,2-c>pyridin-4,6-(5H,7H)-dion
• 英文别名: 3,7-Dideazaxanthin；1,7-dihydro-pyrrolo[3,2-c]pyridine-4,6-dione；1H-Pyrrolo[3,2-c]pyridine-4,6(5H,7H)-dione；1,7-dihydropyrrolo[3,2-c]pyridine-4,6-dione
• CAS: 65523-03-7
• 化学式: C₇H₆N₂O₂
• mdl: MFCD12964786
• 分子量: 150.137
• InChiKey: JXAOFQUVPSCSIF-UHFFFAOYSA-N

物化性质

• 熔点：
  >300 °C(Solv: acetic acid (64-19-7))
• 沸点：
  476.6±45.0 °C(Predicted)
• 密度：
  1.448±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  62
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  3-(Ethoxycarbonyl)pyrrole-2-acetamide 、 sodium hydroxide 以84%的产率得到
  参考文献：
  名称：

  SCHNELLER S. W.; HOSMANE R. S., J. HETEROCYCL. CHEM. , 1977, 14, NO 7, 1291-1292

  摘要：

  DOI：

文献信息

• Devices and Methods for Target Molecule Characterization
  申请人：Lindsay Stuart

  公开号：US20100084276A1

  公开（公告）日：2010-04-08

  The present invention provides a device having at least one constriction that is sized to permit translocation of only a single copy of the molecule. The device has a pair of spaced apart sensing electrodes that border the constriction, which may be a nanopore. The first electrode is connected to a first affinity element and the second electrode is connected to a second affinity element. The first and second affinity elements are configured to temporarily form hydrogen bonds with first and second portions of the target molecule as the latter passes through the constriction.

  本发明提供了一种设备，其具有至少一个狭窄部位，其尺寸仅允许单个分子的横向移动。该设备具有一对间隔的感应电极，其环绕该狭窄部位，该狭窄部位可能是纳米孔。第一电极连接第一亲和元素，第二电极连接第二亲和元素。第一和第二亲和元素被配置为在目标分子通过狭窄部位时，暂时与目标分子的第一和第二部分形成氢键。
• COMPOUNDS FOR TREATING PULMONARY HYPERTENSION
  申请人：Klein Martina

  公开号：US20100113452A1

  公开（公告）日：2010-05-06

  The present invention relates to pharmaceutical compositions and combinations for treating, preventing or managing pulmonary hypertension comprising small molecule heterocyclic pharmaceuticals, and more particularly, substituted pyridines and pyridazines optionally combined with at least one additional therapeutic agent.

  本发明涉及用于治疗、预防或管理肺动脉高压的制药组合物和组合物，包括小分子杂环类药物，特别是取代的吡啶和吡啶二氮杂环，可选地与至少一种其他治疗剂联合使用。
• Devices and methods for target molecule characterization
  申请人：Arizona Board of Regents on behalf of Arizona State University

  公开号：US10330632B2

  公开（公告）日：2019-06-25

  An system for recognition of a translocating polymeric target molecule includes a device having at least one constriction that is sized to permit translocation of only a single copy of the molecule. A pair of spaced apart sensing electrodes border the constriction, which may be a nanopore. The first electrode is connected to a first affinity element and the second electrode is connected to a second affinity element. Each affinity element may connected to its corresponding electrode via one or more intermediary compounds, such as a linker molecule and/or an electrode attachment molecule. The first and second affinity elements are configured to temporarily form hydrogen bonds with first and second portions of the target molecule as the latter passes through the constriction. During translocation, the electrodes affinity elements and first and second portions of the target molecule complete an electrical circuit and allow a measurable electrical current to pass between the first and second electrodes. The time-varying nature of this electrical current, and the specific affinity elements employed, allow one to characterize the target molecule.

  一种用于识别易位聚合目标分子的系统包括一个装置，该装置至少有一个收缩口，其大小只允许分子的一个拷贝易位。一对间隔开的传感电极位于收缩处的边缘，收缩处可以是一个纳米孔。第一电极与第一亲和元件相连，第二电极与第二亲和元件相连。每个亲和元件可通过一个或多个中间化合物（如连接分子和/或电极附着分子）与其相应的电极相连。当目标分子通过收缩时，第一和第二亲和元件被配置为与目标分子的第一和第二部分暂时形成氢键。在转位过程中，电极亲和元件与目标分子的第一和第二部分完成一个电路，并允许可测量的电流在第一和第二电极之间通过。这种电流的时变性和所使用的特定亲和元件，使我们能够确定目标分子的特征。
• SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY
  申请人：BAYER CORPORATION

  公开号：EP1228063B1

  公开（公告）日：2009-02-11
• SCHNELLER S. W.; HOSMANE R. S., J. ORG. CHEM., 1978, 43, NO 23, 4487-4491
  作者：SCHNELLER S. W.、 HOSMANE R. S.

  DOI：——

  日期：——