1H-环戊二烯并[c]异噻唑-4,5,6-三醇,六氢-1-甲基-,[3aR-(3aa,4a,5b,6a,6aa)]-(9CI) | 314776-99-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 中文名称: 1H-环戊二烯并[c]异噻唑-4,5,6-三醇,六氢-1-甲基-,[3aR-(3aa,4a,5b,6a,6aa)]-(9CI)
• 英文名称: (S)-N-(1,2,3,4-Tetrahydronaphthalen-1-yl)formamide
• 英文别名: N-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide
• CAS: 314776-99-3
• 化学式: C₁₁H₁₃NO
• 分子量: 175.23
• InChiKey: SXEPYAAYPZBIEE-NSHDSACASA-N

物化性质

• 沸点：
  368.9±22.0 °C(Predicted)
• 密度：
  1.10±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• TREATMENT OF PAIN DISORDERS WITH trans 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENAMINE AND ITS FORMAMIDE
  申请人：Tarantino Paul Michael

  公开号：US20070282007A1

  公开（公告）日：2007-12-06

  Treatment of pain disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro- 1 -napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful in treatment of pain disorders.

  使用(1R,4S)-反式-4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺和(1S,4R)-反式-4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺治疗疼痛疾病。还公开了一种制备4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺的方法。该方法包括制备N-[4-(3,4-二氯苯基)-1,2,3,4-四氢萘-1-基]甲酰胺的所有四种异构体，这些异构体在治疗疼痛疾病中也有用。
• Combinations of Eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, & Cognitive Disorders
  申请人：Sepracor Inc.

  公开号：EP2455075A1

  公开（公告）日：2012-05-23

  One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.

  本发明的一个方面涉及含有两种或两种以上活性剂的药物组合物，这些活性剂一起服用时可用于治疗更年期、情绪障碍、焦虑症或认知障碍等疾病。药物组合物的第一种成分是镇静剂艾佐匹克隆。药物组合物的第二种成分是反式 4-(3,4-二氯苯基)-1,2,3,4-四氢-N-甲基-1-萘胺或反式 4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺。本发明还涉及一种治疗更年期、围绝经期、情绪障碍、焦虑障碍和认知障碍的方法。
• TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE FOR USE IN TREATMENT OF CNS DISORDERS
  申请人：SEPRACOR, INC.

  公开号：EP1542961B1

  公开（公告）日：2013-09-11
• US8344030B2
  申请人：——

  公开号：US8344030B2

  公开（公告）日：2013-01-01
• [EN] COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT<br/>[FR] COMPOSÉS ET PROCÉDÉS PERMETTANT D'INHIBER LE TRANSPORT DU PHOSPHATE
  申请人：ARDELYX INC

  公开号：WO2012054110A2

  公开（公告）日：2012-04-26

  Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I): (I) including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein X, Y, A, R1 and R2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.