2,2',2''-(1,3,5-三嗪-2,4,6-三基三亚氨基)三乙醇 | 4403-07-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 中文名称: 2,2',2''-(1,3,5-三嗪-2,4,6-三基三亚氨基)三乙醇
• 英文名称: 2,4,6-Tris-<2-hydroxy-ethylamino>-1,3,5-triazin
• 英文别名: 2,4,6-Tris(β-hydroxyethylamino)-s-triazin；N,N,N'-Tris-(2-hydroxymethyl)-melamin；2,4,6-Tris(2-hydroxyethylamino)-1,3,5-triazin；2,2',2''-[1,3,5]triazine-2,4,6-triyltriamino-tris-ethanol；N²,N⁴,N⁶-tris-(2-hydroxy-ethyl)-[1,3,5]triazine-2,4,6-triyltriamine；N²,N⁴,N⁶-Tris-(2-hydroxy-aethyl)-[1,3,5]triazin-2,4,6-triyltriamin；2,2',2''-(1,3,5-triazine-2,4,6-triyltriimino)trisethanol；2-[[4,6-bis(2-hydroxyethylamino)-1,3,5-triazin-2-yl]amino]ethanol
• CAS: 4403-07-0
• 化学式: C₉H₁₈N₆O₃
• 分子量: 258.28
• InChiKey: MNGSQDSFUODZAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  135
• 氢给体数：
  6
• 氢受体数：
  9

安全信息

• 海关编码：
  2933699090

反应信息

• 作为反应物：
  描述：

  2,2',2''-(1,3,5-三嗪-2,4,6-三基三亚氨基)三乙醇 在 三氯氧磷 作用下， 生成 2,3,6,7,10,11-hexahydrotriimidazo[1,2-a:1,2-c:1,2-e][1,3,5]triazine
  参考文献：
  名称：

  Rearrangement Reactions of 1-Aziridinyl-s-triazines; Dihydroimidazo [1,2-a]-s-triazines

  摘要：

  DOI：

  10.1021/ja01627a042
• 作为产物：
  描述：

  2,4,6-三苯氧基-1,3,5-三嗪 、 C.I.酸性橙108 生成 2,2',2''-(1,3,5-三嗪-2,4,6-三基三亚氨基)三乙醇
  参考文献：
  名称：

  Cyanuric Chloride Derivatives. V. Reaction of Alkoxy-s-triazines and Aryloxy-s-triazines with Amines

  摘要：

  DOI：

  10.1021/ja01151a005

文献信息

• New compounds for use in the treatment of cancer
  申请人：JARMAN, Michael

  公开号：EP0505220A1

  公开（公告）日：1992-09-23

  Compounds of the formula: wherein R³ is hydrogen, alkyl or hydroxymethyl, and R¹ and R² are hydrogen, alkyl or an electron withdrawing organic group containing at least two carbon atoms, at least one of R¹ and R² being an electron withdrawing group, and with the proviso that: when R³ is hydroxymethyl, R¹ and R² are electron withdrawing organic groups; are useful in the treatment of cancers, particularly cis-platin resistant ovarian cancer. The new compounds are obtainable by reacting formaldehyde with an intermediate of formula: wherein R3a and R3b are hydrogen, alkyl or hydroxymethyl, but not both hydroxymethyl, and R¹ and R² are hydrogen, alkyl or an electron withdrawing organic group containing at least two carbon atoms, and at least one of R¹ and R² is an electron-withdrawing organic group and where necessary, converting any N-hydroxy-methoxymethyl substituents to N-hydroxymethyl by treatment with an aqueous medium.

  该公式化合物如下：其中R³为氢、烷基或羟甲基，R¹和R²为氢、烷基或含有至少两个碳原子的电子吸引有机基团，R¹和R²中至少有一个为电子吸引基团，且条件是：当R³为羟甲基时，R¹和R²为电子吸引有机基团；这些化合物在治疗癌症中特别是顺铂耐药性卵巢癌方面具有用途。这些新化合物可通过将甲醛与以下中间体反应而获得：其中R3a和R3b为氢、烷基或羟甲基，但不同时为羟甲基，R¹和R²为氢、烷基或含有至少两个碳原子的电子吸引有机基团，R¹和R²中至少有一个为电子吸引有机基团，必要时，通过用水性介质处理将任何N-羟甲氧甲基取代基转化为N-羟甲基。
• [EN] METHOD FOR ALKYLATING AN AMINO COMPOUND<br/>[FR] PROCÉDÉ D'ALKYLATION D'UN COMPOSÉ AMINÉ
  申请人：BOREALIS AGROLINZ MELAMINE

  公开号：WO2018096011A1

  公开（公告）日：2018-05-31

  The invention relates to a method for alkylating an amino compound, characterized in that at least one triazine derivative of general formula (I) or at least one urea or urea derivative of the general formula (II), (II), wherein • R4 and R5 mean independently from each other Q1 or a moiety of the formula R6-N-R7 or R8-N-R9 bound with its central nitrogen atom to the triazine ring of the structure of formula (I), whereat - Q1 means a linear or branched C1-C30-alkyl or a cyclic substituent in form of a C5-C20-cycloalkyl, a C5-C20-aryl, a C1-C20-alkylsubstituted C5-C20-aryl or an amide of a cyclic unsaturated carboxylic acid, whereat the C1-C30-alkyl or the cyclic substituent can be interrupted by one or multiple oxygen atoms, sulphur atoms, substituted nitrogen atoms and/or by one or multiple groups of the type –C(O)O-,-OC(O)-,-C(O)- and/or –OC(O)O-, • R1, R2, R3, R6, R7, R8 and R9 mean independently from each other H, linear or branched C1-C20-alkyl, C5-C20-cyclo alkyl, C5-C20-aryl, C1-C20-alkylsubstituted C5-C20-aryl, which in each case can be interrupted by one or multiple oxygen atoms, sulphur atoms and/or substituted nitrogen atoms and/or by one or multiple groups of the type –C(O)O-, - OC(O)-, -C(O)- and/or –OC(O) O- and/or can be functionalized by one or multiple hydroxyl groups and/or mercapto groups, and • X means O or S, is reacted with at least one alcohol of the general formula (III) R10-OH wherein R10 means a linear or branched C1-C20-alkyl, C5-C20-cycloalkyl, or C1-C20- alkylsubstituted C5-C20-aryl, which can be in each case interrupted by one or multiple oxygen atoms, sulphur atoms, substituted nitrogen atoms and/or by one or multiple groups of the type –C(O)O-, -OC(O)-, -C(O)- and/or –OC(O)O- and/or can be functionalized by one or multiple hydroxyl groups and/or mercapto groups, wherein the reaction is carried out in the presence of at least one Ruthenate of the general formula (IV) Mn(RuO4) and/or at least one Perruthenate of the general formula (V) M(RuO4)n wherein the cation M is selected from a group comprising an alkali, earth alkali or substituted or non-substituted ammonium cation.

  本发明涉及一种烷基化氨基化合物的方法，其特征在于至少使用一种通式(I)的三嗪衍生物或至少使用一种通式(II)的脲或脲衍生物，其中•R4和R5分别独立地表示Q1或式R6-N-R7或R8-N-R9的基团，其中心氮原子与通式(I)的三嗪环结构相连，其中-Q1表示线性或支链的C1-C30烷基或形式为C5-C20环烷基，C5-C20芳基，C1-C20烷基取代的C5-C20芳基或环状不饱和羧酸酰胺的取代基，其中C1-C30烷基或环状取代基可以被一个或多个氧原子，硫原子，取代的氮原子和/或一个或多个-C(O)O-，-OC(O)-，-C(O)-和/或-OC(O)O-类型的基团所中断，•R1，R2，R3，R6，R7，R8和R9分别独立地表示H，线性或支链的C1-C20烷基，C5-C20环烷基，C5-C20芳基，C1-C20烷基取代的C5-C20芳基，其中每种情况都可以被一个或多个氧原子，硫原子和/或取代的氮原子和/或一个或多个-C(O)O-，-OC(O)-，-C(O)-和/或-OC(O)O-类型的基团所中断，并且可以通过一个或多个羟基和/或巯基进行官能化，•X表示O或S，与至少一种通式(III)的醇反应，通式(III)为R10-OH，其中R10表示线性或支链的C1-C20烷基，C5-C20环烷基或C1-C20烷基取代的C5-C20芳基，每种情况都可以被一个或多个氧原子，硫原子，取代的氮原子和/或一个或多个-C(O)O-，-OC(O)-，-C(O)-和/或-OC(O)O-类型的基团所中断，并且可以通过一个或多个羟基和/或巯基进行官能化，其中在至少一种Mn（RuO4）的通式（IV）钌酸盐和/或至少一种M（RuO4）n的通式（V）高钒酸盐的存在下进行反应，其中阳离子M选择自碱金属，碱土金属或取代或未取代的铵阳离子组成的群。
• Coordination-polymeric triethanolamineperchlorato(triflato)metal inner complexes as additives for synthetic polymers
  申请人：Wehner Wolfgang

  公开号：US20090105387A1

  公开（公告）日：2009-04-23

  Stabilizer system for chlorinated polymers, especially PVC, comprising at least one coordination-polymeric triethanolamineperchlorato(triflato)metal inner complex comprising the monomer unit of the formula (A) The stabilizer system may additionally comprise substituted cyanoacetylureas or/and 6-aminouracils or/and 3-aminocrotonic esters or/and hydantoins or/and monomeric or polymeric dihydropyridines or alkaline earth metal hydroxides or/and hydrotalcites or/and dawsonites or/and zeolites or/and glycidyl compounds or/and cyanamides or/and cyanoguanidines or/and melamines. In addition, phosphites or/and sterically hindered amines or/and NOR-HALS compounds may be present.

  氯化聚合物的稳定剂体系，特别是PVC，包括至少一种配位聚合三乙醇胺高氯酸盐（三氟乙酸盐）金属内部络合物，该络合物包括式（A）的单体单位。稳定剂系统还可以包括取代的氰乙酰脲或/和6-氨基尿嘧啶或/和3-氨基巴豆酸酯或/和恒化酮或/和单体或聚合二氢吡啶或碱土金属氢氧化物或/和水滑石或/和道森石或/和沸石或/和环氧丙烷化合物或/和氰胺或/和氰基脲或/和三聚氰胺。此外，磷酸酯或/和立体阻隔胺或/和NOR-HALS化合物也可能存在。
• AROMATIC RING-CONTAINING POLYMER FOR UNDERLAYER OF RESIST AND RESIST UNDERLAYER COMPOSITION INCLUDING THE SAME
  申请人：KIM Min-Soo

  公开号：US20120270994A1

  公开（公告）日：2012-10-25

  An aromatic ring-containing polymer for an underlayer of a resist, including a unit structure represented by Chemical Formula 1:

  一种含有芳香环的聚合物，用于光刻胶的底层，包括由化学式1表示的单元结构。
• COORDINATION-POLYMERIC TRIETHANOLAMINEPERCHLORATO(TRIFLATO)METAL INNER COMPLEXES AS ADDITIVES FOR SYNTHETIC POLYMERS
  申请人：Wehner Wolfgang

  公开号：US20090131564A1

  公开（公告）日：2009-05-21

  Stabilizer system for chlorinated polymers, especially PVC, comprising at least one coordination-polymeric triethanolamineperchlorato(triflato)metal inner complex comprising the monomer unit of the formula (A) The stabilizer system may additionally comprise substituted cyanoacetylureas or/and 6-aminouracils or/and 3-aminocrotonic esters or/and hydantoins or/and monomeric or polymeric dihydropyridines or alkaline earth metal hydroxides or/and hydrotalcites or/and dawsonites or/and zeolites or/and glycidyl compounds or/and cyanamides or/and cyanoguanidines or/and melamines. In addition, phosphites or/and sterically hindered amines or/and NOR-HALS compounds may be present.

  氯化聚合物，尤其是PVC的稳定剂系统，包括至少一个配位聚合三乙醇胺高氯酸盐（三氟甲烷磺酸盐）金属内部配合物，其中包括公式（A）的单体单位。稳定剂系统还可以包括取代的氰乙酰脲或/和6-氨基尿嘧啶或/和3-氨基巴豆酸酯或/和咪唑二酮或/和单体或聚合二氢吡啶或碱土金属氢氧化物或/和水滑石或/和达氏石或/和沸石或/和环氧丙烷化合物或/和氰胺或/和氰基脲或/和三聚氰胺。此外，还可以存在亚磷酸酯或/和立体阻碍胺或/和NOR-HALS化合物。