2,4,6-三甲基-1,3,5-二噻嗪 | 86241-90-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环化合物
• 中文名称: 2,4,6-三甲基-1,3,5-二噻嗪
• 中文别名: 2,4,6-三甲基-1,3,5-二噻嗪烷
• 英文名称: 5,6-dihydro-2,4,6-trimethyl-4H-1,3,5-dithiazine
• 英文别名: 2,4,6-trimethyl-1,3,5-dithiazinane；thialdine；2,4,6-trimethyl-[1,3,5]dithiazinane；2,4,6-trimethyl-dihydro-[1,3,5]dithiazine；2,4,6-Trimethyl-dihydro-[1,3,5]dithiazin；2,4,6-Trimethyldihydro-1,3,5-dithiazin
• CAS: 86241-90-9
• 化学式: C₆H₁₃NS₂
• mdl: MFCD00089205
• 分子量: 163.308
• InChiKey: FBMVFHKKLDGLJA-UHFFFAOYSA-N

物化性质

• 沸点：
  260.7±20.0 °C(Predicted)
• 密度：
  1.011±0.06 g/cm3(Predicted)
• LogP：
  1.85
• 物理描述：
  Light brown crystalline solid; roasted, meaty odour
• 溶解度：
  Insoluble in water, heptane, triacetin
• 保留指数：
  1166.9;1168;1150;1194;1202;1181;1181;1174;1204;1211

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  2,4,6-三甲基-1,3,5-二噻嗪 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以30%的产率得到3,6-二甲基-1,2,4,5-四噻烷
  参考文献：
  名称：

  A Novel Method for the Generation of Thial S-Sulfides from 2,4,6-Trisubstituted 5,6-Dihydro-1,3,5-dithiazines

  摘要：

  用 NCS 或 NBS 处理 2,4,6-三取代的 5,6-二氢-1,3,5-二噻嗪可得到高活性的硫代 S 硫化物，这些硫化物经过二聚反应可得到相应的 1,2,4,5-四噻烷。这些产物经 Ph3P、KCN 或 Na2S4 处理后，还可选择性地转化为天然环状多硫化物、1,2,4-三硫环戊烷和 1,2,3,5,6-五硫环戊烷。

  DOI：

  10.1246/cl.1988.1517
• 作为产物：
  描述：

  2,4,6-trimethyl-hexahydro-[1,3,5]triazine; trihydrate 在 硫化氢 、 水 作用下， 生成 2,4,6-三甲基-1,3,5-二噻嗪
  参考文献：
  名称：

  Woehler; Liebig, Justus Liebigs Annalen der Chemie, 1847, vol. 61, p. 2

  摘要：

  DOI：

文献信息

• 1H-pyrrole-2,4-dicarbonyl-derivatives and their use as flavoring agents
  申请人：IMAX Discovery GmbH

  公开号：EP2832233A1

  公开（公告）日：2015-02-04

  The present invention primarily relates to 1H-pyrrole-2,4-dicarbonyl-derivatives of Formula (I) wherein R1, R2, R3, Z. Z' and J are as defined in the description, to mixtures thereof and to the use thereof as flavoring agents. The compounds in accordance with the present invention are suitable for producing, imparting, or intensifying an umami flavor. The invention further relates to flavoring mixtures, compositions for oral consumption as well as ready-to-eat, ready-to-use and semifinished products, comprising an effective amount of the compound of Formula (I) or of a mixture of compounds of Formula (I) and to specific methods for producing, imparting, modifying and/or intensifying specific flavor impressions.

  本发明主要涉及式(I)的1H-吡咯-2,4-二羰基衍生物，其中R1、R2、R3、Z、Z'和J按描述定义，及其混合物，以及用作调味剂的使用。根据本发明的化合物适用于生产、赋予或增强鲜味。本发明进一步涉及包含式(I)化合物或式(I)化合物混合物的有效量的调味混合物、口腔消费的组成物以及即食、即用和半成品，以及用于生产、赋予、改变和/或增强特定风味印象的特定方法。
• Imidazo[1,2-a]pyridine-ylmethyl-derivatives and their use as flavoring agents
  申请人：IMAX Discovery GmbH

  公开号：EP2832234A1

  公开（公告）日：2015-02-04

  The present invention primarily relates to imidazo[1,2-a]pyridine-ylmethyl-derivatives of Formula (I) wherein R1, R2, X, W e J are as defined in the description, to mixtures thereof and to the use thereof as flavoring agents. The compounds in accordance with the present invention are suitable for producing, imparting, or intensifying an umami flavor. The invention further relates to flavoring mixtures, compositions for oral consumption as well as ready-to-eat, ready-to-use and semifinished products, comprising an effective amount of the compound of Formula (I) and to specific methods for producing, imparting, modifying and/or intensifying specific flavor impressions.

  本发明主要涉及式(I)的咪唑[1,2-a]吡啶基甲基衍生物，其中R1、R2、X、W和J如描述中定义，以及涉及它们的混合物和使用它们作为调味剂。根据本发明的化合物适合于产生、赋予或增强鲜味。本发明进一步涉及调味混合物、口腔摄入的配方以及包含有效量的式(I)化合物的即食、即用和半成品，以及用于生产、赋予、改变和/或增强特定风味印象的特定方法。
• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• Functionalized polymers and improved vulcanizates therefrom
  申请人：Hogan E Terrence

  公开号：US20060074197A1

  公开（公告）日：2006-04-06

  A functionalized polymer defined by the formula π-R 1 -α, where π is a polymer chain, R 1 is a bond or a divalent organic group, and α is a sulfur-containing heterocycle.

  一种由公式π-R1-α定义的功能化聚合物，其中π是聚合物链，R1是键或双价有机基团，α是含硫杂环。

表征谱图