2,4-二氯-8-甲基-10-氧杂-8-氮杂双环[4.4.0]癸-2,4,11-三烯 | 6333-57-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 中文名称: 2,4-二氯-8-甲基-10-氧杂-8-氮杂双环[4.4.0]癸-2,4,11-三烯
• 英文名称: 6,8-Dichloro-3-methyl-3,4-dihydro-2h-1,3-benzoxazine
• 英文别名: 6,8-dichloro-3-methyl-2,4-dihydro-1,3-benzoxazine
• CAS: 6333-57-9
• 化学式: C₉H₉Cl₂NO
• 分子量: 218.08
• InChiKey: WOBGQUOOABOYAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• CCR2 MODULATORS
  申请人：ChemoCentryx, Inc.

  公开号：EP3297438B1

  公开（公告）日：2021-10-20
• US9783540B2
  申请人：——

  公开号：US9783540B2

  公开（公告）日：2017-10-10
• [EN] METHODS OF TREATING SOLID TUMORS WITH CCR2 ANTAGONISTS<br/>[FR] PROCÉDÉS DE TRAITEMENT DE TUMEURS SOLIDES AU MOYEN D'ANTAGONISTES DU CCR2
  申请人：CHEMOCENTRYX INC

  公开号：WO2019136368A2

  公开（公告）日：2019-07-11

  The present disclosure provides, inter alia, methods of treating a solid-tumor by administering an effective amount of a Chemokine Receptor 2 (CCR2) antagonist. Also provided herein are methods of reducing the number of macrophages in a solid tumor microenvironment, said method comprising administering effective amount of a Chemokine Receptor 2 (CCR2) antagonist. In an additional aspect, the current disclosure further provides methods of increasing the number CD8+ T cells in a solid tumor microenvironment, said method comprising administering effective amount of a Chemokine Receptor 2 (CCR2) antagonist. In some embodiments, the CCR2 antagonist has the formula (I).