2,6-二甲基-4(3H)-蝶啶酮 | 34244-77-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 中文名称: 2,6-二甲基-4(3H)-蝶啶酮
• 英文名称: 4-Hydroxy-2,6-dimethyl-pteridin
• 英文别名: 2,6-dimethyl-3H-pteridin-4-one；4(3H)-Pteridinone, 2,6-dimethyl-；2,6-dimethyl-3H-pteridin-4-one
• CAS: 34244-77-4
• 化学式: C₈H₈N₄O
• 分子量: 176.178
• InChiKey: FTYQNNFWGDJXEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] BIFUNCTIONAL FOLATE RECEPTOR BINDING COMPOUNDS<br/>[FR] COMPOSÉS BIFONCTIONNELS DE LIAISON AU RÉCEPTEUR DES FOLATES
  申请人：[en]LYCIA THERAPEUTICS, INC.

  公开号：WO2022150721A1

  公开（公告）日：2022-07-14

  The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface receptor, such as a folate receptor. The cell surface folate binding compound can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor, e.g., folate receptor. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided herein are methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.
• WO2022272307A1
  申请人：——

  公开号：WO2022272307A1

  公开（公告）日：2022-12-29