2,6-双(溴甲基)-N,N-二甲基吡啶-4-胺 | 89593-27-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2,6-双(溴甲基)-N,N-二甲基吡啶-4-胺
• 英文名称: 2,6-bis(bromomethyl)-4-(dimethylamino)pyridine
• 英文别名: 2,6-Bis(brommethyl)-4-(dimethylamino)-pyridin；4-Pyridinamine, 2,6-bis(bromomethyl)-N,N-dimethyl-；2,6-bis(bromomethyl)-N,N-dimethylpyridin-4-amine
• CAS: 89593-27-1
• 化学式: C₉H₁₂Br₂N₂
• 分子量: 308.016
• InChiKey: VAGPFBRWQWPANW-UHFFFAOYSA-N

物化性质

• 沸点：
  365.1±42.0 °C(Predicted)
• 密度：
  1.714±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,6-双(溴甲基)-N,N-二甲基吡啶-4-胺 在 barium dihydroxide 作用下， 以 水 、 苯 为溶剂， 反应 8.0h， 生成 4-(Dimethylamino)-2,6-pyridinbis(methylamin)-N,N,N',N'-tetraessigsaeure
  参考文献：
  名称：

  Voegtle, Fritz; Ohm, Christian, Chemische Berichte, 1984, vol. 117, # 3, p. 948 - 954

  摘要：

  DOI：
• 作为产物：
  描述：

  dimethyl 4-(dimethylamino)pyridine-2,6-dicarboxylate 在 sodium tetrahydroborate 、 三溴化磷 作用下， 以 乙醇 、 氯仿 为溶剂， 反应 19.0h， 生成 2,6-双(溴甲基)-N,N-二甲基吡啶-4-胺
  参考文献：
  名称：

  Voegtle, Fritz; Ohm, Christian, Chemische Berichte, 1984, vol. 117, # 3, p. 948 - 954

  摘要：

  DOI：

文献信息

• Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Aβ fibril formation
  作者：Seong Rim Byeon、Ji Hoon Lee、Ji-Hoon Sohn、Dong Chan Kim、Kye Jung Shin、Kyung Ho Yoo、Inhee Mook-Jung、Won Koo Lee、Dong Jin Kim

  DOI：10.1016/j.bmcl.2006.10.090

  日期：2007.3

  New bis-styrylpyridine and bis-styrylbenzene derivatives were designed and synthesized. These 34 compounds were evaluated by A beta fibril formation inhibitory assay using thioflavin T as a dye (named ThT assay). Most of them showed excellent inhibitory activities for A beta fibril formation at IC50 of 0.1-2.7 mu M which is comparable to curcumin (IC50 of 0.8 mu M). Among them, nine compounds were screened for their cytotoxicities on HT-22 cell by MTT assay at 1, 10, and 50 mu M. In particular, 1-7 and II-2 exhibited the best combination of inhibitory activity and compound cytotoxicity. (c) 2006 Elsevier Ltd. All rights reserved.
• Effect of Cavity Size on Supramolecular Stability
  作者：B. J. Whitlock、H. W. Whitlock

  DOI：10.1021/ja00085a009

  日期：1994.3

  We describe the synthesis of a boxlike cyclophane 1, its complexation with p-nitrophenol, the temperature dependence of the H-1 NMR spectra of the 1:p-nitrophenol complex, and the effect of solvent on complexation. Cyclophane 1 was designed to test our previous observations on the effect of cavity size and pi-hydrogen bonds in stabilizing host-guest complexes in nonpolar solvents. It exhibits an association constant with p-nitrophenol in excess of 400 000 M-1 in CDCl3. The high stability of the complex is paralleled by slow exchange between free and complexed cyclophane. The axial spinning of the xylene units of the host is slow in the complex but fast in the free host. It is shown that the rate-determining step for xylene spinning is dissociation of the complex. The two guest protons ortho to the nitro group in the phenol are distinct in the complex; their interconversion requires its dissociation. Both K(assoc) and k(exch) are dependent on the solvent. Solvents that are ''big'' (chloroform and tetrachloroethane) exhibit large K(assoc) values and slow exchange, while small'' solvents (dichloromethane and 1,2-dichloroethane) exhibit both smaller K(assoc) values and faster exchange. These solvent effects are interpreted in terms of a binding model involving displacement of one intracavity species by another.
• Voegtle, Fritz; Ohm, Christian, Chemische Berichte, 1984, vol. 117, # 3, p. 948 - 954
  作者：Voegtle, Fritz、Ohm, Christian

  DOI：——

  日期：——