2,7-二(2-甲基吗啉基)-4-(N-乙醇-N-异丙醇)氨基-6-苯基蝶啶 | 25000-95-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 中文名称: 2,7-二(2-甲基吗啉基)-4-(N-乙醇-N-异丙醇)氨基-6-苯基蝶啶
• 中文别名: L-丝氨酸,2-[(2,3,4-三羟基苯基)甲基]酰肼,盐酸(1:1)
• 英文名称: 2-Propanol, 1-((2,7-bis(2-methyl-4-morpholinyl)-6-phenyl-4-pteridinyl)(2-hydroxyethyl)amino)-
• 英文别名: 1-[[2,7-bis(2-methylmorpholin-4-yl)-6-phenylpteridin-4-yl]-(2-hydroxyethyl)amino]propan-2-ol
• CAS: 25000-95-7
• 化学式: C₂₇H₃₇N₇O₄
• 分子量: 523.6
• InChiKey: RLNCPIGDMLKAML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF MUSCULOSKELETAL DISORDERS AND SYMPTOMS ASSOCIATED THEREWITH
  申请人：CombinatoRx, Incorporated

  公开号：EP1999626A2

  公开（公告）日：2008-12-10
• Methods, compositions, and kits for the treatment of musculoskeletal disorders and symptoms associated therewith
  申请人：Lessem N. Jan

  公开号：US20070213308A1

  公开（公告）日：2007-09-13

  The invention features methods, compositions, and kits for treating a musculoskeletal disorder, e.g., osteoarthritis, or pain, fatigue, tenderness, impairment in mobility, soft tissue swelling, or bony swelling associated therewith, by administering to a patient diagnosed with or at risk of developing such pain, fatigue, tenderness, impairment in mobility, soft tissue swelling, or bony swelling a tetra-substituted pyrimidopyrimidine, e.g., dipyridamole, or an adenosine activity upregulator, in combination with one or more additional agents. The invention further features methods, compositions, and kits for treating a patient diagnosed with or at risk of developing a musculoskeletal disorder by administering to the patient a tetra-substituted pyrimidopyrimidine or an adenosine activity upregulator in combination with one or more additional agents.
• Methods and compositions for the treatment of diseases or conditions associated with increased C-reactive protein, interleukin-6, or interferon-gamma levels
  申请人：Lessem Jan

  公开号：US20080003213A1

  公开（公告）日：2008-01-03

  The invention features methods and compositions for reducing the serum C-reactive protein (CRP), IL-6, and/or IFN-γ levels in a patient in need thereof, and for treating diseases and conditions associated with an increased serum CRP, IL-6, and/or IFN-γ levels. The invention also features methods and compositions for treating a patient diagnosed with, or at risk of developing, periodontal disease by administering a corticosteroid or an analog thereof and/or a tetra-substituted pyrimidopyrimidine or an adenosine analog upregulator.
• Methods and compositions for the treatment of diseases or conditions associated with increased C-reactive protein levels
  申请人：Lessem Jan

  公开号：US20080025965A1

  公开（公告）日：2008-01-31

  The invention features methods and compositions for reducing the serum C-reactive protein (CRP) level in a patient in need thereof, and for treating diseases and conditions associated with an increased serum CRP level. The invention also features methods and compositions for treating a patient diagnosed with, or at risk of developing, periodontal disease by administering a tricyclic compound or an analog thereof and/or a tetra-substituted pyrimidopyrimidine or an analog thereof. The invention also features methods and compositions for reducing the serum CRP level in a patient in need thereof, and for treating diseases and conditions associated with an increased serum CRP level.
• Compositions and methods for treating medical conditions
  申请人：Lessem Jan

  公开号：US20090005358A1

  公开（公告）日：2009-01-01

  The invention features methods, compositions, and kits for the treatment of pain or pruritus in a patient. In one embodiment, the methods, compositions, and kits of the invention provide for a combination therapy including a tricyclic compound and a tetra-substituted pyrimidopyrimidine.