5-((Bis(methylamino)methyl)imino)-1,3,3,4-tetramethyl-1,4,2-diazaphospholidin-2-ol 2-oxide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: 5-((Bis(methylamino)methyl)imino)-1,3,3,4-tetramethyl-1,4,2-diazaphospholidin-2-ol 2-oxide
• 英文别名: 1-[(E)-(2-hydroxy-1,3,3,4-tetramethyl-2-oxo-1,4,2λ5-diazaphospholidin-5-ylidene)amino]-N,N'-dimethylmethanediamine
• 化学式: C₉H₂₂N₅O₂P
• 分子量: 263.28
• InChiKey: HFUUVNATNQAXQK-XYOKQWHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  80.2
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• SYNCHRONIZATION OF ION GENERATION WITH CYCLING OF A DISCONTINUOUS ATMOSPHERIC INTERFACE
  申请人：Purdue Research Foundation

  公开号：US20140051180A1

  公开（公告）日：2014-02-20

  The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

  本发明通常涉及用于离子生成与不连续大气界面循环同步的方法和装置。在某些实施例中，本发明提供了一种用于分析样品的系统，包括质谱探针，生成样品离子，不连续大气界面和质谱分析器，其中该系统被配置为使离子形成与不连续大气界面的循环同步。
• Synchronization of ion generation with cycling of a discontinuous atmospheric interface
  申请人：Purdue Research Foundation

  公开号：US10361073B2

  公开（公告）日：2019-07-23

  The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

  本发明一般涉及离子生成与不连续大气界面循环同步的方法和装置。在某些实施方案中，本发明提供了一种用于分析样品的系统，该系统包括一个产生样品离子的质谱探针、一个不连续大气界面和一个质量分析器，其中系统的配置使离子的形成与不连续大气界面的循环同步。
• NOVEL DRUG TARGETS TO OVERCOME DE NOVO DRUG-RESISTANCE IN MULTIPLE MYELOMA
  申请人：University of Florida Research Foundation, Inc.

  公开号：US20130281389A1

  公开（公告）日：2013-10-24

  Topoisomerase II alpha (topo IIα) is exported from the cell nucleus in human myeloma cells by a chromosome-maintenance protein-1 (CRM1)-dependent mechanism, resulting in topo II inhibitor resistance. The nuclear export signal (NES) of topo IIα is unique, making it a potential target for small molecule inhibitors. Small molecules NES inhibitors were identified, which inhibited binding of topo IIα to the export receptor CRM1. Inhibition was specific to topo IIα as p53 trafficking was unaffected along with topo IIα protein expression and function (decatenation). These topo IIα-specific nuclear export inhibitors may potentially lead to a new approach in circumventing drug resistance in multiple myeloma. The compounds provide a protocol for treating multiple myeloma or an oncogenic disease. Further, the topoisomerase II nuclear export signal inhibitor may be combined with a topoisomerase II inhibitor.
• US9184036B2
  申请人：——

  公开号：US9184036B2

  公开（公告）日：2015-11-10
• US9500623B2
  申请人：——

  公开号：US9500623B2

  公开（公告）日：2016-11-22