2-(1H-苯并咪唑-2-基)-1,3-苯并恶唑 | 14595-67-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 中文名称: 2-(1H-苯并咪唑-2-基)-1,3-苯并恶唑
• 英文名称: 2-Benzoxazol-2-yl-benzimidazol
• 英文别名: 2--benzoxazol；2-(1H-benzoimidazol-2-yl)-benzooxazole；2-(1H-benzimidazol-2-yl)benzoxazole；2-(1H-Benzimidazol-2-yl)-1,3-benzoxazole
• CAS: 14595-67-6
• 化学式: C₁₄H₉N₃O
• 分子量: 235.245
• InChiKey: IOKQVGHOQCPQNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  benzooxazole-2-carbothioyl chloride 、 邻苯二胺 生成 2-(1H-苯并咪唑-2-基)-1,3-苯并恶唑
  参考文献：
  名称：

  Oka,K.; Hara,S., Heterocycles, 1977, vol. 6, p. 941 - 944

  摘要：

  DOI：

文献信息

• Synthesis of benzoxazoles, benzothiazoles and benzimidazoles and evaluation of their antifungal, insecticidal and herbicidal activities.
  作者：TAKUZO HISANO、MASATAKA ICHIKAWA、KONOSUKE TSUMOTO、MASANOBU TASAKI

  DOI：10.1248/cpb.30.2996

  日期：——

  Benzoxazoles, benzothiazoles and benzimidazoles having substituents on the azole and benzene nuclei were synthesized evaluated for antifungal, insecticidal and herbicidal activities. It was found that benzimidazoles tended to exhibit antifungal activity while benzothiazoles tended to show herbicidal activity. Chloro, trifluoromethyl, methoxy and ethoxy groups at the 5 position were potent substituents, and the 2-pyridyl group at the 2 position is a common structural unit. Among several active derivatives, 7-chloro-2-(2-pyridyl) benzimidazole and 2-(2-pyridyl)-5-trifluoromethylbenzothiazole exhibited significant activity against Panonycus citri.

  合成了在偶氮和苯环上具有取代基的苯并噁唑、苯并噻唑和苯并咪唑，并评估其抗真菌、杀虫和除草活性。研究发现，苯并咪唑倾向于表现出抗真菌活性，而苯并噻唑则倾向于显示除草活性。在5位位置上的氯、三氟甲基、甲氧基和乙氧基基团是有效的取代基，而在2位位置的吡啶基是一个常见的结构单元。在几种具有活性的衍生物中，7-氯-2-(2-吡啶基)苯并咪唑和2-(2-吡啶基)-5-三氟甲基苯并噻唑对柑橘红蜘蛛表现出显著活性。
• 2-Trihalogenomethylbenzazoles. Part IV. Reactions with difunctional nucleophiles. Formation of heterocyclic rings on the 2-position of benzazoles
  作者：B. C. Ennis、G. Holan、E. L. Samuel

  DOI：10.1039/j39670000033

  日期：——

  1,4-difunctional nucleophiles. Similarly, aromatic ortho-disubstituted nucleophiles yielded the corresponding azole derivatives. Other heterocyclic rings on the 2-position of benzimidazole were formed in reactions with semicarbazide and mercaptoethanol. The nature and activation of the trihalogenomethyl groups in these cyclisations is discussed, and some reactions of the cyclisation products are also

  选定的2-三卤代甲基苯并咪唑与1,2-双官能胺，氨基醇和氨基硫醇的反应形成在2-位被2-咪唑啉-2-基，2-恶唑啉-2-基和2取代的苯并咪唑-噻唑啉-2-基环。通过三卤代甲基与1，3-和1，4-双官能亲核试剂的反应，这种高产率方法扩展到六元和七元环类似物的形成。类似地，芳族邻二取代亲核试剂产生相应的唑衍生物。在苯并咪唑和巯基乙醇的反应中形成了苯并咪唑2位上的其他杂环。讨论了这些环化反应中三卤代甲基的性质和活化，并且还报道了环化产物的一些反应。
• Chromophore Coated Metal Oxide Particles
  申请人：Schehlmann Volker

  公开号：US20090291107A1

  公开（公告）日：2009-11-26

  The invention provides coated metal oxide particles, wherein metal oxide particles are coated with at least one type of crosslinkable chromophore with UV-A and/or UV-B and/or UV-C filter and/or broadband activity and optionally at least one type of crosslinkable monomer which does not have UV-A and/or UV-B and/or UV-C and/or broadband filter activity and process to obtain coated metal oxide particles and their use especially in cosmetic or dermatological formulations for the protection against harmful effects of sunlight.

  该发明提供了一种涂覆金属氧化物颗粒的方法，其中金属氧化物颗粒被至少一种具有UV-A和/或UV-B和/或UV-C和/或宽带活性的可交联色团涂覆，并且可选择涂覆至少一种不具有UV-A和/或UV-B和/或UV-C和/或宽带过滤活性的可交联单体，以及获得涂覆金属氧化物颗粒的过程和它们在化妆品或皮肤科配方中的使用，以保护皮肤免受阳光的有害影响。
• Microcapsules with uv filter activity and process for producing them
  申请人：Berg-Schultz Katja

  公开号：US20070190325A1

  公开（公告）日：2007-08-16

  The invention provides a process for producing microcapsules with UV filter activity, wherein at least one type of crosslinkable chromophore with UV-A and/or UV-B and/or UV-C filter activity and optionally at least one type of crosslinkable monomer which does not have UV-A and/or UV-B and/or UV-C filter activity are subjected to a crosslinking reaction in the absence of non-crosslinkable chromophores with UV-A and/or UV-B and/or UV-C filter activity and microcapsules obtainable by this process.

  本发明提供一种制备具有UV过滤活性的微胶囊的方法，其中至少一种具有UV-A和/或UV-B和/或UV-C过滤活性的可交联色团和可选地至少一种不具有UV-A和/或UV-B和/或UV-C过滤活性的可交联单体在无不可交联的具有UV-A和/或UV-B和/或UV-C过滤活性的色团的情况下进行交联反应，并获得由此过程获得的微胶囊。
• MICROCAPSULES WITH UV FILTER ACTIVITY AND PROCESS FOR PRODUCING THEM
  申请人：BERG-SCHULTZ Katja

  公开号：US20120022265A1

  公开（公告）日：2012-01-26

  The invention provides a process for producing microcapsules with UV filter activity, wherein at least one type of crosslinkable chromophore with UV-A and/or UV-B and/or UV-C filter activity and optionally at least one type of crosslinkable monomer which does not have UV-A and/or UV-B and/or UV-C filter activity are subjected to a crosslinking reaction in the absence of non-crosslinkable chromophores with UV-A and/or UV-B and/or UV-C filter activity and microcapsules obtainable by this process.

  本发明提供了一种用于生产具有UV过滤活性的微胶囊的方法，其中至少一种具有UV-A和/或UV-B和/或UV-C过滤活性的可交联色团和可选地至少一种不具有UV-A和/或UV-B和/或UV-C过滤活性的可交联单体在不存在不可交联的具有UV-A和/或UV-B和/或UV-C过滤活性的色团的情况下进行交联反应，以及通过该方法获得的微胶囊。