2,4,5-trimethyl-3H-pyrrole

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,4,5-trimethyl-3H-pyrrole
• 化学式: C₇H₁₁N
• 分子量: 109.17
• InChiKey: ZAYSLRHTTQNNQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES
  申请人：Meerpoel Lieven

  公开号：US20140045827A1

  公开（公告）日：2014-02-13

  The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives of Formula (I) wherein R 1 , R 2 , R 3 , R 4 and Het have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

  本发明涉及一种新型抗真菌5,6-二氢-4H-吡咯并-[1,2-a][1,4]苯二氮杂环和6H-吡咯并[1,2-a][1,4]苯二氮杂环，其取代有Formula (I)中的杂环衍生物的R1、R2、R3、R4和Het的含义如权利要求中所定义。根据本发明的化合物主要对抗皮肤真菌和全身真菌感染有效。本发明还涉及制备这种新型化合物的方法，含有该化合物作为活性成分的药物组合物，以及将该化合物用作药物的用途。
• Fungicide n-cycloalkyl-carboxamide, thiocarboxamide and n-substituted-carboximidamide derivatives
  申请人：Desbordes Philippe

  公开号：US20090270461A1

  公开（公告）日：2009-10-29

  The present invention relates to N-cycloalkyl-carboxamide, N-cycloalkyl-thiocarboxamide and N-cycloalkyl-N-substituted carboximidamide derivatives of formula (I) wherein A represents carbo-linked, 5-membered heterocyclyl groups, T represents O, S, NR c , N—OR d , N—NR c R d or N—CN, Z 1 represents cycloalkyl groups and Z 2 and Z 3 , W 1 to W 5 represent various substituents; their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.

  本发明涉及公式（I）的N-环烷基-羧酰胺，N-环烷基-硫代羧酰胺和N-环烷基-N-取代羧酰亚胺衍生物，其中A代表碳链连接的五元杂环基团，T代表O，S，NRc，N—ORd，N—NRcRd或N—CN，Z1代表环烷基团，Z2和Z3，W1至W5代表各种取代基；它们的制备方法，它们作为杀真菌活性剂的用途，特别是以真菌杀剂组成的形式，以及使用这些化合物或组合物控制植物病原真菌，尤其是植物的方法。
• 1-Substituted-4-Nitroimidazole Compound and Method for Preparing the Same
  申请人：GOTO Fumitaka

  公开号：US20120130082A1

  公开（公告）日：2012-05-24

  The present invention relates to a 1-substituted-4-nitroimidazole compound represented by the general formula (1) or a salt thereof, (wherein R is a hydrogen atom, a lower alkoxy group-substituted lower alkyl group, a phenyl-lower alkoxy group-substituted lower alkyl group, a cyano-substituted lower alkyl group, a phenyl-lower alkyl group which may have lower alkoxy groups as the substituents in the phenyl ring or a group of the formula —CH 2 R A ; X is a halogen atom or a group of the formula —S(O)n-R 1 ) and method for preparing the same. The compound of the formula (1) is a useful compound as an intermediate for synthesis of various pharmaceutical and agricultural chemicals, particularly, as intermediates for antitubercular agents.

  本发明涉及一种由通式（1）表示的1-取代-4-硝基咪唑化合物或其盐（其中R为氢原子，低烷氧基取代的低烷基，苯基-低烷氧基取代的低烷基，氰基取代的低烷基，苯基-低烷基，其苯环上可能带有低烷氧基取代物，或者为公式—CH2RA的基团；X为卤素原子或公式—S（O）n-R1的基团），以及制备该化合物的方法。公式（1）的化合物是一种有用的中间体，可用于合成各种医药和农业化学品，特别是抗结核药物的中间体。
• ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US20130090364A1

  公开（公告）日：2013-04-11

  Compounds represented by formula I or pharmaceutically acceptable salts thereof, wherein A, B, B′, X, Y, R 1 , R 2 , R 2 ′, R 3 , R 3 ′, R 4 , R 4 ′, R 5 , R 5 ′m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

  以公式I表示的化合物或其药学上可接受的盐，其中A、B、B′、X、Y、R1、R2、R2′、R3、R3′、R4、R4′、R5、R5′、m、n或p的定义如本文所述，对于治疗黄病毒科病毒感染是有用的。
• OREXIN RECEPTOR ANTAGONISTS WHICH ARE [ORTHO BI-(HETERO-)ARYL]-[2-(META BI-(HETERO-)ARYL)-PYRROLIDIN-1-YL]-METHANONE DERIVATIVES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：US20150252032A1

  公开（公告）日：2015-09-10

  The present invention relates to [ortho bi-(hetero-)aryl]-[2-(meta bi-(hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives of formula (I) wherein R, and the rings A 1 A 2 and A 3 are as described in the description, to pharmaceutically acceptable salts thereof, to their preparation, to pharmaceutical compositions containing one or more compounds of formula (I), and to their use as pharmaceuticals, especially to their use as orexin receptor antagonists.

  本发明涉及公式（I）的[ortho bi-（hetero-）aryl]-[2-（meta bi-（hetero-）aryl）-pyrrolidin-1-yl]-methanone衍生物，其中R和环A1A2和A3如描述中所述，以及其药学上可接受的盐、其制备方法、含有一个或多个公式（I）化合物的制药组合物以及它们作为药物的用途，特别是作为促进睡眠激素受体拮抗剂的用途。