N-(6,6-dimethoxy-5,7-dihydro-4H-1,3-benzothiazol-2-yl)acetamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(6,6-dimethoxy-5,7-dihydro-4H-1,3-benzothiazol-2-yl)acetamide
• 化学式: C₁₁H₁₆N₂O₃S
• 分子量: 256.32
• InChiKey: KYCVIUQQSHDBCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  88.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Process for preparation of 2-amino-6 (alkyl) amino-4,5,6,7-tetrahydrobenzothiazoles
  申请人：——

  公开号：US20040029936A1

  公开（公告）日：2004-02-12

  A new process to obtain pramipexole and related products is described. The process involves the reaction of new compounds of formula (6), wherein R is hydrogen or acyl group, R 3 and R 4 are either the same and each of them represents an alkoxy group of 1-4 carbons or they together form a C 2 -C 5 alkylenedioxy group or an oxo-group, with an alkylamine in the presence of a reducing agent or a hydrogen gas with hydrogenation catalyst. A process to obtain new compounds of formula (6) is also described.

  描述了一种获取普拉米贝克索和相关产品的新工艺。该工艺涉及新化合物的反应，其化学式为（6），其中R为氢或酰基，R3和R4可以相同，且分别代表1-4碳原子的烷氧基，或它们一起形成一个C2-C5烷二氧基基团或一个氧基团，与一种烷基胺在还原剂或氢气与加氢催化剂的存在下发生反应。还描述了一种获得新化合物的工艺，其化学式为（6）。
• PROCESS FOR PREPARATION OF 2-AMINO-6-(ALKYL) AMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLES
  申请人：Synthon B.V.

  公开号：EP1318986A1

  公开（公告）日：2003-06-18
• US6770761B2
  申请人：——

  公开号：US6770761B2

  公开（公告）日：2004-08-03
• [EN] PROCESS FOR PREPARATION OF 2-AMINO-6-(ALKYL) AMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLES<br/>[FR] PROCEDE DE PREPARATION DE 2-AMINO-6(ALKYL)AMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLES
  申请人：SYNTHON BV

  公开号：WO2002022590A1

  公开（公告）日：2002-03-21

  A new process to obtain pramipexole and related products is described. The process involves the reaction of new compounds of formula (6), wherein R is hydrogen or acyl group, R3 and R4 are either the same and each of them represents an alkoxy group of 1-4 carbons or they together form a C2-C5 alkylenedioxy group or an oxo-group, with an alkylamine in the presence of a reducing agent or a hydrogen gas with hydrogenation catalyst. A process to obtain new compounds of formula (6) is also described.