N-[2-(2,4-dichlorophenyl)-4-quinazolinyl]-N-(1H-indazol-5-yl)amine | 461036-81-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-[2-(2,4-dichlorophenyl)-4-quinazolinyl]-N-(1H-indazol-5-yl)amine
• 英文别名: 2-(2,4-dichlorophenyl)-N-(1H-indazol-5-yl)quinazolin-4-amine
• CAS: 461036-81-7
• 化学式: C₂₁H₁₃Cl₂N₅
• 分子量: 406.274
• InChiKey: YFPSTOIYUHHQBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Rho-kinase inhibitors
  申请人：Nagarathnam Dhanaphalan

  公开号：US20060142313A1

  公开（公告）日：2006-06-29

  Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

  本发明涉及化合物及其衍生物、其合成和作为Rho-激酶抑制剂的用途。本发明的这些化合物对于抑制肿瘤生长、治疗勃起功能障碍以及治疗其他由Rho-激酶介导的适应症（例如冠心病）非常有用。
• RHO-KINASE INHIBITORS
  申请人：Nagarathnam Dhanaphalan

  公开号：US20100137324A1

  公开（公告）日：2010-06-03

  Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

  本发明揭示了化合物及其衍生物，它们的合成以及它们作为Rho-激酶抑制剂的用途。本发明的这些化合物对于抑制肿瘤生长、治疗勃起功能障碍以及治疗其他由Rho-激酶介导的适应症，例如冠心病，是有用的。
• COMBINATION THERAPY FOR PULMONARY ARTERIAL HYPERTENSION
  申请人：ROSCIGNO Robert

  公开号：US20090036465A1

  公开（公告）日：2009-02-05

  Methods for treatment of pulmonary hypertension include administration of a first amount of treprostinil and administration of a second amount of a Rho kinase inhibitor such that the first amount and the second amount form together an amount effective for pulmonary hypertension treatment. Kits for treatment pulmonary hypertension are also disclosed.
• [EN] RHO-KINASE INHIBITORS<br/>[FR] INHIBITEURS DE RHO-KINASE
  申请人：BAYER AG

  公开号：WO2002076976A2

  公开（公告）日：2002-10-03

  Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
• [EN] USE OF RHO-KINASE INHIBITORS IN THE TREATMENT OF ANEURYSM AND CARDIAC HYPERTROPHY<br/>[FR] UTILISATION DES INHIBITEURS DE LA RHO KINASE DANS LE TRAITEMENT DE L'ANEVRISME ET DE L'HYPERTROPHIE CARDIAQUE
  申请人：SCHERING AG

  公开号：WO2004105757A2

  公开（公告）日：2004-12-09

  The present invention is directed to a method for preventing or decreasing the incidence of or treating aneurysm or cardiac hypertrophy, comprising administering an effective amount of a rhokinase inhibitor, such as fasudil, to a subject in need thereof.