2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile;(8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile;(8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione
• 化学式: C37H43N5O2
• 分子量: 589.8
• InChiKey: INOBPGWIELHSTE-YFDMJGHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.96
• 重原子数：
  44
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  112
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• METHODS OF ENHANCING THE ACCURACY AND/OR SENSITIVITY OF ULTRASOUND IMAGING IN DIAGNOSING TUMORS
  申请人：Academia Sinica

  公开号：US20210113179A1

  公开（公告）日：2021-04-22

  Disclosed herein is a method of enhancing the accuracy and/or sensitivity of ultrasound imaging in detecting a tumor in a subject. The method comprises administering to the subject an effective amount of a nanoparticle prior to the application of ultrasound to the subject. According to certain embodiments of the present disclosure, the nanoparticle is a magnetic nanoparticle, for example, a gold, silver, or iron oxide nanoparticle. Also disclosed herein are methods of treating a tumor in a subject by detecting the tumor via ultrasound with the aid of a nanoparticle, and then administering to the subject an anti-cancer treatment based on the location of the tumor revealed by the ultrasound image.
• US9987326B2
  申请人：——

  公开号：US9987326B2

  公开（公告）日：2018-06-05