(Z) 2-{5-[4-(Hexyl-methyl-amino)-benzylidene]4-oxo-2-thioxo-thiazolidin-3-yl}-ethanesulfonic acid methylamide | 313514-39-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (Z) 2-{5-[4-(Hexyl-methyl-amino)-benzylidene]4-oxo-2-thioxo-thiazolidin-3-yl}-ethanesulfonic acid methylamide
• 英文别名: 2-[(5Z)-5-[[4-[hexyl(methyl)amino]phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-methylethanesulfonamide
• CAS: 313514-39-5
• 化学式: C₂₀H₂₉N₃O₃S₃
• 分子量: 455.667
• InChiKey: VPXYSQOBJVPUEV-SDXDJHTJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  136
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Method of imaging amyloid deposits using substituted rhodanine derivatives
  申请人：——

  公开号：US20040197268A1

  公开（公告）日：2004-10-07

  The present invention provides a method of treating Alzheimer's disease using a compound of Formula I 1 Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula I and a method of imaging amyloid deposits using substituted rhodanine derivatives.

  本发明提供了一种使用I式化合物治疗阿尔茨海默病的方法。同时，还提供了一种使用I式化合物抑制淀粉样蛋白聚集的方法和使用取代罗丹明衍生物成像淀粉样沉积物的方法。
• RHODANINE DERIVATIVES AND THEIR USE IN INHIBITING AND IMAGING AMYLOIDS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1192144A1

  公开（公告）日：2002-04-03
• [EN] RHODANINE DERIVATIVES AND THEIR USE IN INHIBITING AND IMAGING AMYLOIDS<br/>[FR] DERIVES DE LA RHODANINE ET LEUR UTILISATION POUR L'INHIBITION ET LA MISE EN IMAGES D'AMYLOIDES
  申请人：WARNER LAMBERT CO

  公开号：WO2000076988A1

  公开（公告）日：2000-12-21

  The present invention provides a method of treating Alzheimer's disease using a compound of Formula (I). Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula (I) and a method of imaging amyloid deposits using substituted rhodanine derivatives.