2-Hexadecyl-N-(2-hydroxyethyl)-3-oxo-eicosanamide | 253871-44-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Hexadecyl-N-(2-hydroxyethyl)-3-oxo-eicosanamide
• 英文别名: 2-hexadecyl-N-(2-hydroxyethyl)-3-oxoicosanamide
• CAS: 253871-44-2
• 化学式: C₃₈H₇₅NO₃
• 分子量: 594.0
• InChiKey: LUPQUWPDYZNMKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.6
• 重原子数：
  42
• 可旋转键数：
  35
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Use of PPAR-alpha activator as inflammatory skin disease-treating agent and method for treating skin diseases using the same
  申请人：Park Byeong-Deog

  公开号：US20100173995A1

  公开（公告）日：2010-07-08

  Disclosed herein is the use of a non-natural compound represented by the following formula 1 as an activator of the peroxisome proliferator activated receptor-α (PPAR-α) which shows an anti-inflammatory effect on inflammatory skin diseases. The PPAR-α activator increases the expression of PPAR-α in the skin to enhance various physiological effects of PPAR-α, that is, the anti-inflammatory effect caused by inhibiting the activity of transcription factors such as the nuclear factor κK (NF-κK) that induces inflammatory reactions, the effect of improving the epidermal permeability barrier function of the skin, and the effect of promoting the terminal differentiation of epidermal keratinocytes. Thus, the PPAR-α activator is useful for the treatment, alleviation or amelioration of skin diseases such as acne, seborrheic dermatitis, viral skin diseases, urticaria, pruritus, viral infectious diseases and contact dermatitis. wherein R 1 and R 2 are the same or different and each represents a linear or branched C 1-22 alkyl group, a phenyl group or a benzene group.