N-tert-Butyl-N'-[2,2-dimethyl-prop-(E)-ylidene]-formamidine | 30834-74-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-tert-Butyl-N'-[2,2-dimethyl-prop-(E)-ylidene]-formamidine
• 英文别名: 1,4-Di-tert-butyl-1,3-diazabutadiene；N'-tert-butyl-N-(2,2-dimethylpropylidene)methanimidamide
• CAS: 30834-74-3
• 化学式: C₁₀H₂₀N₂
• 分子量: 168.282
• InChiKey: OPPRKNJUOUATHM-UHFFFAOYSA-N

物化性质

• 熔点：
  32-36 °C
• 沸点：
  225.0±23.0 °C(Predicted)
• 密度：
  0.80±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  24.7
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1-乙氧基羰基甲基)-2,2,5,5-四甲基-1-氮杂-2,5-二硅杂环戊烷 、 N-tert-Butyl-N'-[2,2-dimethyl-prop-(E)-ylidene]-formamidine 生成 trans-1-tert-Butyl-3-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-4-(N-tert-butyliminomethyl)-2-azetidinone
  参考文献：
  名称：

  Stereoselective synthesis of cis- and trans-.beta.-lactams via .alpha.-amino ester enolates and 1-aza-4-hetero-1,3-butadiene systems. Molecular structure of [cyclic] EtOC(O)C(H)(NEt2)C(H)(N(H)-tert-Bu)C(H):N(tert-Bu)ZnCl2: An unexpectedly isolated aldolate

  摘要：

  Lithium and zinc enolates of N,N-diprotected glycine esters 1 react with 1-aza-4-hetero-1,3-butadiene systems 4 selectively affording cis- and trans-3-amino-4-functionalized-2-azetidinones in excellent yields, respectively. The reactions with 1,4-diaza-1,3-butadiene systems are far more selective (de greater-than-or-equal-to 90%) than those with 1-aza-4-oxo- and 1-aza-4-thio-1,3-butadiene systems (de 0-85%). In apolar solvents some of the reactions between the zinc enolates 2 and functionalized imines 4 partly stop at the stage of the C-C coupled product, probably because the metal center migrates to a chelating position between the nitrogen and the hetero atom of the imine. Consequently, elimination of the metal alkoxide and ring closure to a 2-azetidinone product is not likely to occur anymore. This view is supported by the isolation and structural characterization of a ZnCl2 complex of a C-C coupled product, erythro-EtOC(O)C(H)(NEt2)C(H) activated (N(H)-t-Bu)C(H) = N(t-Bu)ZnCl2 (8), which furthermore demonstrates that erythro C-C bond formation leads to a trans-2-azetidinone product. In polar solvents the migration of the metal center is prevented and exclusively 2-azetidinone products are isolated.

  DOI：

  10.1021/jo00020a031

文献信息

• Thermally stable volatile precursors
  申请人：Winter Charles H.

  公开号：US09255327B2

  公开（公告）日：2016-02-09

  A method of forming a thin film on a substrate which includes a step of contacting a surface with a precursor compound having a transition metal and one or more alkyl-1,3-diazabutadiene ligands is provided. The resulting modified surface is then contacted with an activating compound.

  提供了一种在基板上形成薄膜的方法，其中包括将含有过渡金属和一个或多个烷基-1,3-二氮基丁二烯配体的前体化合物与表面接触的步骤。然后将得到的修饰表面与活化化合物接触。
• THERMALLY STABLE VOLATILE PRECURSORS
  申请人：WAYNE STATE UNIVERSITY

  公开号：US20160152650A1

  公开（公告）日：2016-06-02

  A method of forming a thin film on a substrate which includes a step of contacting a surface with a precursor compound having a transition metal and one or more alkyl-1,3-diazabutadiene ligands is provided. The resulting modified surface is then contacted with an activating compound.

  提供了一种在基底上形成薄膜的方法，其中包括与具有过渡金属和一个或多个烷基-1,3-二氮基丁二烯配体的前体化合物接触表面的步骤。然后将得到的修饰表面与激活化合物接触。